CAR+ and CAR− T cells share a differentiation trajectory into an NK-like subset after CD19 CAR T cell infusion in patients with B cell malignancies
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DOI: 10.1038/s41467-023-43656-7
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- J. Joseph Melenhorst & Gregory M. Chen & Meng Wang & David L. Porter & Changya Chen & McKensie A. Collins & Peng Gao & Shovik Bandyopadhyay & Hongxing Sun & Ziran Zhao & Stefan Lundh & Iulian Pruteanu, 2022. "Decade-long leukaemia remissions with persistence of CD4+ CAR T cells," Nature, Nature, vol. 602(7897), pages 503-509, February.
- Curtis Cai & Jerome Samir & Mehdi R. Pirozyan & Thiruni N. Adikari & Money Gupta & Preston Leung & Brendan Hughes & Willem Byl & Simone Rizzetto & Auda Elthala & Elizabeth Keoshkerian & Jean-Louis Pal, 2022. "Identification of human progenitors of exhausted CD8+ T cells associated with elevated IFN-γ response in early phase of viral infection," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
- Jordan W. Squair & Matthieu Gautier & Claudia Kathe & Mark A. Anderson & Nicholas D. James & Thomas H. Hutson & Rémi Hudelle & Taha Qaiser & Kaya J. E. Matson & Quentin Barraud & Ariel J. Levine & Gio, 2021. "Confronting false discoveries in single-cell differential expression," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
- Rachel C. Lynn & Evan W. Weber & Elena Sotillo & David Gennert & Peng Xu & Zinaida Good & Hima Anbunathan & John Lattin & Robert Jones & Victor Tieu & Surya Nagaraja & Jeffrey Granja & Charles F. A. B, 2019. "c-Jun overexpression in CAR T cells induces exhaustion resistance," Nature, Nature, vol. 576(7786), pages 293-300, December.
- J. Joseph Melenhorst & Gregory M. Chen & Meng Wang & David L. Porter & Changya Chen & McKensie A. Collins & Peng Gao & Shovik Bandyopadhyay & Hongxing Sun & Ziran Zhao & Stefan Lundh & Iulian Pruteanu, 2022. "Author Correction: Decade-long leukaemia remissions with persistence of CD4+ CAR T cells," Nature, Nature, vol. 612(7941), pages 22-22, December.
- Mandeep Singh & Ghamdan Al-Eryani & Shaun Carswell & James M. Ferguson & James Blackburn & Kirston Barton & Daniel Roden & Fabio Luciani & Tri Giang Phan & Simon Junankar & Katherine Jackson & Christo, 2019. "High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
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