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A synthetic metastatic niche reveals antitumor neutrophils drive breast cancer metastatic dormancy in the lungs

Author

Listed:
  • Jing Wang

    (University of Michigan
    Iowa State University)

  • Ramon Ocadiz-Ruiz

    (University of Michigan)

  • Matthew S. Hall

    (University of Michigan)

  • Grace G. Bushnell

    (University of Michigan)

  • Sophia M. Orbach

    (University of Michigan)

  • Joseph T. Decker

    (University of Michigan
    University of Michigan School of Dentistry)

  • Ravi M. Raghani

    (University of Michigan)

  • Yining Zhang

    (University of Michigan)

  • Aaron H. Morris

    (University of Michigan
    University of Michigan)

  • Jacqueline S. Jeruss

    (University of Michigan
    University of Michigan)

  • Lonnie D. Shea

    (University of Michigan
    University of Michigan
    University of Michigan)

Abstract

Biomaterial scaffolds mimicking the environment in metastatic organs can deconstruct complex signals and facilitate the study of cancer progression and metastasis. Here we report that a subcutaneous scaffold implant in mouse models of metastatic breast cancer in female mice recruits lung-tropic circulating tumor cells yet suppresses their growth through potent in situ antitumor immunity. In contrast, the lung, the endogenous metastatic organ for these models, develops lethal metastases in aggressive breast cancer, with less aggressive tumor models developing dormant lungs suppressing tumor growth. Our study reveals multifaceted roles of neutrophils in regulating metastasis. Breast cancer-educated neutrophils infiltrate the scaffold implants and lungs, secreting the same signal to attract lung-tropic circulating tumor cells. Second, antitumor and pro-tumor neutrophils are selectively recruited to the dormant scaffolds and lungs, respectively, responding to distinct groups of chemoattractants to establish activated or suppressive immune environments that direct different fates of cancer cells.

Suggested Citation

  • Jing Wang & Ramon Ocadiz-Ruiz & Matthew S. Hall & Grace G. Bushnell & Sophia M. Orbach & Joseph T. Decker & Ravi M. Raghani & Yining Zhang & Aaron H. Morris & Jacqueline S. Jeruss & Lonnie D. Shea, 2023. "A synthetic metastatic niche reveals antitumor neutrophils drive breast cancer metastatic dormancy in the lungs," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40478-5
    DOI: 10.1038/s41467-023-40478-5
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