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Context-dependent function of TSLP and IL-1β in skin allergic sensitization and atopic march

Author

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  • Justine Segaud

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg)

  • Wenjin Yao

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg)

  • Pierre Marschall

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg)

  • François Daubeuf

    (CNRS-Strasbourg University, UAR3286, Plate-Forme de Chimie Biologique Intégrative de Strasbourg/Strasbourg Drug Discovery and Development Institute, ESBS
    CNRS-Strasbourg University, UMR7200, Laboratoire d’Innovation Thérapeutique/ Strasbourg Drug Discovery and Development Institute, Faculté de Pharmacie)

  • Christine Lehalle

    (CNRS-Strasbourg University, UAR3286, Plate-Forme de Chimie Biologique Intégrative de Strasbourg/Strasbourg Drug Discovery and Development Institute, ESBS
    CNRS-Strasbourg University, UMR7200, Laboratoire d’Innovation Thérapeutique/ Strasbourg Drug Discovery and Development Institute, Faculté de Pharmacie)

  • Beatriz German

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg)

  • Pierre Meyer

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg)

  • Pierre Hener

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg)

  • Cécile Hugel

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg)

  • Eric Flatter

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg)

  • Marine Guivarch

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg)

  • Laetitia Clauss

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg)

  • Stefan F. Martin

    (Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg)

  • Mustapha Oulad-Abdelghani

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg)

  • Mei Li

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 - Inserm U 1258 – Université de Strasbourg)

Abstract

Atopic diseases, including atopic dermatitis (AD) and asthma, affect a large proportion of the population, with increasing prevalence worldwide. AD often precedes the development of asthma, known as the atopic march. Allergen sensitization developed through the barrier-defective skin of AD has been recognized to be a critical step leading to asthma, in which thymic stromal lymphopoietin (TSLP) was previously shown to be critical. In this study, using a laser-assistant microporation system to disrupt targeted skin layers for generating micropores at a precise anatomic depth of mouse skin, we model allergen exposure superficially or deeply in the skin, leading to epicutaneous sensitization or dermacutaneous sensitization that is associated with a different cytokine microenvironment. Our work shows a differential requirement for TSLP in these two contexts, and identifies an important function for IL-1β, which is independent of TSLP, in promoting allergen sensitization and subsequent allergic asthma.

Suggested Citation

  • Justine Segaud & Wenjin Yao & Pierre Marschall & François Daubeuf & Christine Lehalle & Beatriz German & Pierre Meyer & Pierre Hener & Cécile Hugel & Eric Flatter & Marine Guivarch & Laetitia Clauss &, 2022. "Context-dependent function of TSLP and IL-1β in skin allergic sensitization and atopic march," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32196-1
    DOI: 10.1038/s41467-022-32196-1
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    References listed on IDEAS

    as
    1. Gael Boivin & Julien Faget & Pierre-Benoit Ancey & Aspasia Gkasti & Julie Mussard & Camilla Engblom & Christina Pfirschke & Caroline Contat & Justine Pascual & Jessica Vazquez & Nathalie Bendriss-Verm, 2020. "Durable and controlled depletion of neutrophils in mice," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    2. Juan Manuel Leyva-Castillo & Pierre Hener & Paula Michea & Hajime Karasuyama & Susan Chan & Vassili Soumelis & Mei Li, 2013. "Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade," Nature Communications, Nature, vol. 4(1), pages 1-12, December.
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