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Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis

Author

Listed:
  • Aaron H. Morris

    (University of Michigan)

  • Kevin R. Hughes

    (University of Michigan)

  • Robert S. Oakes

    (University of Michigan)

  • Michelle M. Cai

    (University of Michigan)

  • Stephen D. Miller

    (Northwestern University Feinberg School of Medicine)

  • David N. Irani

    (University of Michigan Medical School)

  • Lonnie D. Shea

    (University of Michigan
    University of Michigan)

Abstract

Relapses in multiple sclerosis can result in irreversible nervous system tissue injury. If these events could be detected early, targeted immunotherapy could potentially slow disease progression. We describe the use of engineered biomaterial-based immunological niches amenable to biopsy to provide insights into the phenotype of innate immune cells that control disease activity in a mouse model of multiple sclerosis. Differential gene expression in cells from these niches allow monitoring of disease dynamics and gauging the effectiveness of treatment. A proactive treatment regimen, given in response to signal within the niche but before symptoms appeared, substantially reduced disease. This technology offers a new approach to monitor organ-specific autoimmunity, and represents a platform to analyze immune dysfunction within otherwise inaccessible target tissues.

Suggested Citation

  • Aaron H. Morris & Kevin R. Hughes & Robert S. Oakes & Michelle M. Cai & Stephen D. Miller & David N. Irani & Lonnie D. Shea, 2020. "Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17629-z
    DOI: 10.1038/s41467-020-17629-z
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    Cited by:

    1. Jing Wang & Ramon Ocadiz-Ruiz & Matthew S. Hall & Grace G. Bushnell & Sophia M. Orbach & Joseph T. Decker & Ravi M. Raghani & Yining Zhang & Aaron H. Morris & Jacqueline S. Jeruss & Lonnie D. Shea, 2023. "A synthetic metastatic niche reveals antitumor neutrophils drive breast cancer metastatic dormancy in the lungs," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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