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Genes that mediate breast cancer metastasis to lung

Author

Listed:
  • Andy J. Minn

    (Memorial Sloan-Kettering Cancer Center
    Memorial Sloan-Kettering Cancer Center)

  • Gaorav P. Gupta

    (Memorial Sloan-Kettering Cancer Center)

  • Peter M. Siegel

    (Memorial Sloan-Kettering Cancer Center
    McGill University Health Centre)

  • Paula D. Bos

    (Memorial Sloan-Kettering Cancer Center)

  • Weiping Shu

    (Memorial Sloan-Kettering Cancer Center)

  • Dilip D. Giri

    (Memorial Sloan-Kettering Cancer Center
    Brown University)

  • Agnes Viale

    (Memorial Sloan-Kettering Cancer Center)

  • Adam B. Olshen

    (Memorial Sloan-Kettering Cancer Center)

  • William L. Gerald

    (Memorial Sloan-Kettering Cancer Center)

  • Joan Massagué

    (Memorial Sloan-Kettering Cancer Center
    Memorial Sloan-Kettering Cancer Center)

Abstract

By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.

Suggested Citation

  • Andy J. Minn & Gaorav P. Gupta & Peter M. Siegel & Paula D. Bos & Weiping Shu & Dilip D. Giri & Agnes Viale & Adam B. Olshen & William L. Gerald & Joan Massagué, 2005. "Genes that mediate breast cancer metastasis to lung," Nature, Nature, vol. 436(7050), pages 518-524, July.
    • Handle: RePEc:nat:nature:v:436:y:2005:i:7050:d:10.1038_nature03799
    DOI: 10.1038/nature03799
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    1. Xun Yuan & Mingsheng Zhang & Hua Wu & Hanxiao Xu & Na Han & Qian Chu & Shiying Yu & Yuan Chen & Kongming Wu, 2015. "Expression of Notch1 Correlates with Breast Cancer Progression and Prognosis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-13, June.
    2. Xiaomei Li & Lin Liu & Gregory J Goodall & Andreas Schreiber & Taosheng Xu & Jiuyong Li & Thuc D Le, 2020. "A novel single-cell based method for breast cancer prognosis," PLOS Computational Biology, Public Library of Science, vol. 16(8), pages 1-20, August.
    3. Parker Hilary S. & Leek Jeffrey T., 2012. "The practical effect of batch on genomic prediction," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 11(3), pages 1-22, April.
    4. Markus Ringnér & Erik Fredlund & Jari Häkkinen & Åke Borg & Johan Staaf, 2011. "GOBO: Gene Expression-Based Outcome for Breast Cancer Online," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-11, March.
    5. Won Jun Lee & Sang Cheol Kim & Jung-Ho Yoon & Sang Jun Yoon & Johan Lim & You-Sun Kim & Sung Won Kwon & Jeong Hill Park, 2016. "Meta-Analysis of Tumor Stem-Like Breast Cancer Cells Using Gene Set and Network Analysis," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-20, February.
    6. Isabel Tundidor & Marta Seijo-Vila & Sandra Blasco-Benito & María Rubert-Hernández & Sandra Adámez & Clara Andradas & Sara Manzano & Isabel Álvarez-López & Cristina Sarasqueta & María Villa-Morales & , 2023. "Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    7. Xianhui Ruan & Wei Yan & Minghui Cao & Ray Anthony M. Daza & Miranda Y. Fong & Kaifu Yang & Jun Wu & Xuxiang Liu & Melanie Palomares & Xiwei Wu & Arthur Li & Yuan Chen & Rahul Jandial & Nicholas C. Sp, 2024. "Breast cancer cell-secreted miR-199b-5p hijacks neurometabolic coupling to promote brain metastasis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    8. Herman M J Sontrop & Wim F J Verhaegh & Marcel J T Reinders & Perry D Moerland, 2011. "An Evaluation Protocol for Subtype-Specific Breast Cancer Event Prediction," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-12, July.
    9. Jing Wang & Ramon Ocadiz-Ruiz & Matthew S. Hall & Grace G. Bushnell & Sophia M. Orbach & Joseph T. Decker & Ravi M. Raghani & Yining Zhang & Aaron H. Morris & Jacqueline S. Jeruss & Lonnie D. Shea, 2023. "A synthetic metastatic niche reveals antitumor neutrophils drive breast cancer metastatic dormancy in the lungs," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    10. R Joseph Bender & Feilim Mac Gabhann, 2013. "Expression of VEGF and Semaphorin Genes Define Subgroups of Triple Negative Breast Cancer," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-15, May.
    11. Shijun Ma & Yue Zhao & Wee Chyan Lee & Li-Teng Ong & Puay Leng Lee & Zemin Jiang & Gokce Oguz & Zhitong Niu & Min Liu & Jian Yuan Goh & Wenyu Wang & Matias A. Bustos & Sidse Ehmsen & Adaikalavan Ramas, 2022. "Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    12. Xi Zhao & Einar Andreas Rødland & Therese Sørlie & Bjørn Naume & Anita Langerød & Arnoldo Frigessi & Vessela N Kristensen & Anne-Lise Børresen-Dale & Ole Christian Lingjærde, 2011. "Combining Gene Signatures Improves Prediction of Breast Cancer Survival," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-15, March.
    13. Veronika Bandara & Jade Foeng & Batjargal Gundsambuu & Todd S. Norton & Silvana Napoli & Dylan J. McPeake & Timona S. Tyllis & Elaheh Rohani-Rad & Caitlin Abbott & Stuart J. Mills & Lih Y. Tan & Emma , 2023. "Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    14. Hyun Gyu Lee & Kyoung J Lee, 2021. "Neighbor-enhanced diffusivity in dense, cohesive cell populations," PLOS Computational Biology, Public Library of Science, vol. 17(9), pages 1-26, September.
    15. Bo Jiang & Xiaozhi Zhao & Wei Chen & Wenli Diao & Meng Ding & Haixiang Qin & Binghua Li & Wenmin Cao & Wei Chen & Yao Fu & Kuiqiang He & Jie Gao & Mengxia Chen & Tingsheng Lin & Yongming Deng & Chao Y, 2022. "Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    16. Seyedeh Fatemeh Razavipour & Hyunho Yoon & Kibeom Jang & Minsoon Kim & Hend M. Nawara & Amir Bagheri & Wei-Chi Huang & Miyoung Shin & Dekuang Zhao & Zhiqun Zhou & Derek Boven & Karoline Briegel & Llui, 2024. "C-terminally phosphorylated p27 activates self-renewal driver genes to program cancer stem cell expansion, mammary hyperplasia and cancer," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    17. Wenbin Xu & Han Yao & Zhen Wu & Xiaojun Yan & Zishan Jiao & Yajing Liu & Meng Zhang & Donglai Wang, 2024. "Oncoprotein SET-associated transcription factor ZBTB11 triggers lung cancer metastasis," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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