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Genetic risk, adherence to healthy lifestyle and acute cardiovascular and thromboembolic complications following SARS-COV-2 infection

Author

Listed:
  • Junqing Xie

    (University of Oxford)

  • Yuliang Feng

    (University of Oxford
    Southern University of Science and Technology)

  • Danielle Newby

    (University of Oxford)

  • Bang Zheng

    (London School of Hygiene & Tropical Medicine)

  • Qi Feng

    (University of Oxford)

  • Albert Prats-Uribe

    (University of Oxford)

  • Chunxiao Li

    (University of Cambridge)

  • Nicholas J. Wareham

    (University of Cambridge)

  • R. Paredes

    (Hospital Universitari Germans 13 Trias i Pujol
    Case Western Reserve University School of Medicine)

  • Daniel Prieto-Alhambra

    (University of Oxford
    Erasmus Medical Center University)

Abstract

Current understanding of determinants for COVID-19-related cardiovascular and thromboembolic (CVE) complications primarily covers clinical aspects with limited knowledge on genetics and lifestyles. Here, we analysed a prospective cohort of 106,005 participants from UK Biobank with confirmed SARS-CoV-2 infection. We show that higher polygenic risk scores, indicating individual’s hereditary risk, were linearly associated with increased risks of post-COVID-19 atrial fibrillation (adjusted HR 1.52 [95% CI 1.44 to 1.60] per standard deviation increase), coronary artery disease (1.57 [1.46 to 1.69]), venous thromboembolism (1.33 [1.18 to 1.50]), and ischaemic stroke (1.27 [1.05 to 1.55]). These genetic associations are robust across genders, key clinical subgroups, and during Omicron waves. However, a prior composite healthier lifestyle was consistently associated with a reduction in all outcomes. Our findings highlight that host genetics and lifestyle independently affect the occurrence of CVE complications in the acute infection phrase, which can guide tailored management of COVID-19 patients and inform population lifestyle interventions to offset the elevated cardiovascular burden post-pandemic.

Suggested Citation

  • Junqing Xie & Yuliang Feng & Danielle Newby & Bang Zheng & Qi Feng & Albert Prats-Uribe & Chunxiao Li & Nicholas J. Wareham & R. Paredes & Daniel Prieto-Alhambra, 2023. "Genetic risk, adherence to healthy lifestyle and acute cardiovascular and thromboembolic complications following SARS-COV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40310-0
    DOI: 10.1038/s41467-023-40310-0
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    References listed on IDEAS

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    1. Gad Abraham & Rainer Malik & Ekaterina Yonova-Doing & Agus Salim & Tingting Wang & John Danesh & Adam S. Butterworth & Joanna M. M. Howson & Michael Inouye & Martin Dichgans, 2019. "Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    2. Nigel Mackman, 2008. "Triggers, targets and treatments for thrombosis," Nature, Nature, vol. 451(7181), pages 914-918, February.
    3. Clare Bycroft & Colin Freeman & Desislava Petkova & Gavin Band & Lloyd T. Elliott & Kevin Sharp & Allan Motyer & Damjan Vukcevic & Olivier Delaneau & Jared O’Connell & Adrian Cortes & Samantha Welsh &, 2018. "The UK Biobank resource with deep phenotyping and genomic data," Nature, Nature, vol. 562(7726), pages 203-209, October.
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    Cited by:

    1. Yunhe Wang & Binbin Su & Marta Alcalde-Herraiz & Nicola L. Barclay & Yaohua Tian & Chunxiao Li & Nicholas J. Wareham & Roger Paredes & Junqing Xie & Daniel Prieto-Alhambra, 2024. "Modifiable lifestyle factors and the risk of post-COVID-19 multisystem sequelae, hospitalization, and death," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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