IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v451y2008i7181d10.1038_nature06797.html
   My bibliography  Save this article

Triggers, targets and treatments for thrombosis

Author

Listed:
  • Nigel Mackman

    (University of North Carolina)

Abstract

Thrombosis — localized clotting of the blood — can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the developed world. Venous thromboembolism is the third leading cause of cardiovascular-associated death. The pathogenic changes that occur in the blood vessel wall and in the blood itself resulting in thrombosis are not fully understood. Understanding these processes is crucial for developing safer and more effective antithrombotic drugs.

Suggested Citation

  • Nigel Mackman, 2008. "Triggers, targets and treatments for thrombosis," Nature, Nature, vol. 451(7181), pages 914-918, February.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7181:d:10.1038_nature06797
    DOI: 10.1038/nature06797
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06797
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06797?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Chanel C. La & Stephanie A. Smith & Sreeparna Vappala & Reheman Adili & Catherine E. Luke & Srinivas Abbina & Haiming D. Luo & Irina Chafeeva & Matthew Drayton & Louise A. Creagh & Maria Guadalupe Jar, 2023. "Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Junqing Xie & Yuliang Feng & Danielle Newby & Bang Zheng & Qi Feng & Albert Prats-Uribe & Chunxiao Li & Nicholas J. Wareham & R. Paredes & Daniel Prieto-Alhambra, 2023. "Genetic risk, adherence to healthy lifestyle and acute cardiovascular and thromboembolic complications following SARS-COV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Hongyuan Zhang & Zhiqiang Zhao & Shengnan Sun & Sen Zhang & Yuequan Wang & Xuanbo Zhang & Jin Sun & Zhonggui He & Shenwu Zhang & Cong Luo, 2023. "Molecularly self‐fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Wonjun Yim & Zhicheng Jin & Yu-Ci Chang & Carlos Brambila & Matthew N. Creyer & Chuxuan Ling & Tengyu He & Yi Li & Maurice Retout & William F. Penny & Jiajing Zhou & Jesse V. Jokerst, 2024. "Polyphenol-stabilized coacervates for enzyme-triggered drug delivery," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    5. Michel W J Smeets & Ruben Bierings & Henriet Meems & Frederik P J Mul & Dirk Geerts & Alexander P J Vlaar & Jan Voorberg & Peter L Hordijk, 2017. "Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-19, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:451:y:2008:i:7181:d:10.1038_nature06797. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.