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Triggers, targets and treatments for thrombosis

Author

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  • Nigel Mackman

    (University of North Carolina)

Abstract

Thrombosis — localized clotting of the blood — can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction (heart attack) and of about 80% of strokes, collectively the most common cause of death in the developed world. Venous thromboembolism is the third leading cause of cardiovascular-associated death. The pathogenic changes that occur in the blood vessel wall and in the blood itself resulting in thrombosis are not fully understood. Understanding these processes is crucial for developing safer and more effective antithrombotic drugs.

Suggested Citation

  • Nigel Mackman, 2008. "Triggers, targets and treatments for thrombosis," Nature, Nature, vol. 451(7181), pages 914-918, February.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7181:d:10.1038_nature06797
    DOI: 10.1038/nature06797
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    Cited by:

    1. Chanel C. La & Stephanie A. Smith & Sreeparna Vappala & Reheman Adili & Catherine E. Luke & Srinivas Abbina & Haiming D. Luo & Irina Chafeeva & Matthew Drayton & Louise A. Creagh & Maria Guadalupe Jar, 2023. "Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Wonjun Yim & Zhicheng Jin & Yu-Ci Chang & Carlos Brambila & Matthew N. Creyer & Chuxuan Ling & Tengyu He & Yi Li & Maurice Retout & William F. Penny & Jiajing Zhou & Jesse V. Jokerst, 2024. "Polyphenol-stabilized coacervates for enzyme-triggered drug delivery," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Michel W J Smeets & Ruben Bierings & Henriet Meems & Frederik P J Mul & Dirk Geerts & Alexander P J Vlaar & Jan Voorberg & Peter L Hordijk, 2017. "Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-19, March.
    4. Junqing Xie & Yuliang Feng & Danielle Newby & Bang Zheng & Qi Feng & Albert Prats-Uribe & Chunxiao Li & Nicholas J. Wareham & R. Paredes & Daniel Prieto-Alhambra, 2023. "Genetic risk, adherence to healthy lifestyle and acute cardiovascular and thromboembolic complications following SARS-COV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    5. Hongyuan Zhang & Zhiqiang Zhao & Shengnan Sun & Sen Zhang & Yuequan Wang & Xuanbo Zhang & Jin Sun & Zhonggui He & Shenwu Zhang & Cong Luo, 2023. "Molecularly self‐fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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