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MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters

Author

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  • Dongmei Wang

    (Northwestern University Feinberg School of Medicine
    Northwestern University Feinberg School of Medicine)

  • Haimin Li

    (Northwestern University Feinberg School of Medicine)

  • Navdeep S. Chandel

    (Northwestern University Feinberg School of Medicine
    Northwestern University Feinberg School of Medicine)

  • Yali Dou

    (University of Southern California)

  • Rui Yi

    (Northwestern University Feinberg School of Medicine
    Northwestern University Feinberg School of Medicine
    Northwestern University Feinberg School of Medicine)

Abstract

Histone H4 lysine 16 acetylation (H4K16ac), governed by the histone acetyltransferase MOF, orchestrates gene expression regulation and chromatin interaction. However, the roles of MOF and H4K16ac in controlling cellular function and regulating mammalian tissue development remain unclear. Here we show that conditional deletion of Mof in the skin, but not Kansl1, causes severe defects in the self-renewal of basal epithelial progenitors, epidermal differentiation, and hair follicle growth, resulting in barrier defects and perinatal lethality. MOF-regulated genes are highly enriched for essential functions in the mitochondria and cilia. Genetic deletion of Uqcrq, an essential subunit for the electron transport chain (ETC) Complex III, in the skin, recapitulates the defects in epidermal differentiation and hair follicle growth observed in MOF knockout mouse. Together, this study reveals the requirement of MOF-mediated epigenetic mechanism for regulating mitochondrial and ciliary gene expression and underscores the important function of the MOF/ETC axis for mammalian skin development.

Suggested Citation

  • Dongmei Wang & Haimin Li & Navdeep S. Chandel & Yali Dou & Rui Yi, 2023. "MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40108-0
    DOI: 10.1038/s41467-023-40108-0
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