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A unique chromatin signature uncovers early developmental enhancers in humans

Author

Listed:
  • Alvaro Rada-Iglesias

    (Stanford University School of Medicine)

  • Ruchi Bajpai

    (Stanford University School of Medicine)

  • Tomek Swigut

    (Stanford University School of Medicine)

  • Samantha A. Brugmann

    (Stanford University School of Medicine)

  • Ryan A. Flynn

    (Stanford University School of Medicine)

  • Joanna Wysocka

    (Stanford University School of Medicine
    Stanford University School of Medicine)

Abstract

Early enhancers revealed Identifying the genomic regulatory sequences, such as enhancers, that control early embryonic development remains a difficult challenge. Profiling of histone modifications and chromatin regulators in human embryonic stem cells now reveals unique signatures that are used to identify more than 2,000 putative enhancers. These enhancers are either active in the embryonic stem cells or are associated with early developmental genes.

Suggested Citation

  • Alvaro Rada-Iglesias & Ruchi Bajpai & Tomek Swigut & Samantha A. Brugmann & Ryan A. Flynn & Joanna Wysocka, 2011. "A unique chromatin signature uncovers early developmental enhancers in humans," Nature, Nature, vol. 470(7333), pages 279-283, February.
    • Handle: RePEc:nat:nature:v:470:y:2011:i:7333:d:10.1038_nature09692
    DOI: 10.1038/nature09692
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    2. Fabrice Darbellay & Anna Ramisch & Lucille Lopez-Delisle & Michael Kosicki & Antonella Rauseo & Zahra Jouini & Axel Visel & Guillaume Andrey, 2024. "Pre-hypertrophic chondrogenic enhancer landscape of limb and axial skeleton development," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Yanting Luo & Jianlin He & Xiguang Xu & Ming-an Sun & Xiaowei Wu & Xuemei Lu & Hehuang Xie, 2018. "Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells," PLOS Computational Biology, Public Library of Science, vol. 14(3), pages 1-21, March.
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    13. M S Vijayabaskar & Debbie K Goode & Nadine Obier & Monika Lichtinger & Amber M L Emmett & Fatin N Zainul Abidin & Nisar Shar & Rebecca Hannah & Salam A Assi & Michael Lie-A-Ling & Berthold Gottgens & , 2019. "Identification of gene specific cis-regulatory elements during differentiation of mouse embryonic stem cells: An integrative approach using high-throughput datasets," PLOS Computational Biology, Public Library of Science, vol. 15(11), pages 1-29, November.
    14. Michael S. Werner & Tobias Loschko & Thomas King & Shelley Reich & Tobias Theska & Mirita Franz-Wachtel & Boris Macek & Ralf J. Sommer, 2023. "Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
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