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Asymmetric cell divisions promote stratification and differentiation of mammalian skin

Author

Listed:
  • Terry Lechler

    (The Rockefeller University)

  • Elaine Fuchs

    (The Rockefeller University)

Abstract

Under your skin To perform its function as an effective physical barrier our skin forms several layers of epidermal cells that are continually renewed. How this process occurs has been unclear, but previous studies in cultured skin cells suggested that stem cells at the base of the epidermis form new cells that migrate outwards to the skin surface. Work on mouse embryos now shows that the parent stem cells anchored at the base of the epidermis have the novel ability to replicate asymmetrically. They generate a ‘suprabasal’ cell, packed with integrins and growth factors, that stays put and above it a proliferative basal cell primed for differentiation and migration.

Suggested Citation

  • Terry Lechler & Elaine Fuchs, 2005. "Asymmetric cell divisions promote stratification and differentiation of mammalian skin," Nature, Nature, vol. 437(7056), pages 275-280, September.
    • Handle: RePEc:nat:nature:v:437:y:2005:i:7056:d:10.1038_nature03922
    DOI: 10.1038/nature03922
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    Cited by:

    1. Zhengcheng He & Ryan Ghorayeb & Susanna Tan & Ke Chen & Amanda C. Lorentzian & Jack Bottyan & Syed Mohammed Musheer Aalam & Miguel Angel Pujana & Philipp F. Lange & Nagarajan Kannan & Connie J. Eaves , 2022. "Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Dongmei Wang & Haimin Li & Navdeep S. Chandel & Yali Dou & Rui Yi, 2023. "MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Elle Koren & Alona Feldman & Marianna Yusupova & Avihay Kadosh & Egor Sedov & Roi Ankawa & Yahav Yosefzon & Waseem Nasser & Stefanie Gerstberger & Liam B. Kimel & Noa Priselac & Samara Brown & Sam Sha, 2022. "Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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