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ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19

Author

Listed:
  • Maik Pietzner

    (Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
    MRC Epidemiology Unit, University of Cambridge)

  • Robert Lorenz Chua

    (Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin)

  • Eleanor Wheeler

    (MRC Epidemiology Unit, University of Cambridge)

  • Katharina Jechow

    (Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin)

  • Julian D. S. Willett

    (McGill University
    Jewish General Hospital)

  • Helena Radbruch

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt-Universität zu Berlin)

  • Saskia Trump

    (Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin)

  • Bettina Heidecker

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt-Universität zu Berlin)

  • Hugo Zeberg

    (Max Planck Institute for Evolutionary Anthropology
    Karolinska Institutet)

  • Frank L. Heppner

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt-Universität zu Berlin
    Cluster of Excellence, NeuroCure
    German Center for Neurodegenerative Diseases (DZNE) Berlin)

  • Roland Eils

    (Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
    Health Data Science Unit, Heidelberg University Hospital and BioQuant
    German Center for Lung Research (DZL), associated partner site)

  • Marcus A. Mall

    (German Center for Lung Research (DZL), associated partner site
    Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    Berlin Institute of Health at Charité – Universitätsmedizin Berlin)

  • J. Brent Richards

    (McGill University
    Jewish General Hospital
    McGill University
    King’s College London)

  • Leif-Erik Sander

    (Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH))

  • Irina Lehmann

    (Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
    German Center for Lung Research (DZL), associated partner site)

  • Sören Lukassen

    (Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin)

  • Nicholas J. Wareham

    (MRC Epidemiology Unit, University of Cambridge)

  • Christian Conrad

    (Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin)

  • Claudia Langenberg

    (Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin
    MRC Epidemiology Unit, University of Cambridge)

Abstract

Despite two years of intense global research activity, host genetic factors that predispose to a poorer prognosis of COVID-19 infection remain poorly understood. Here, we prioritise eight robust (e.g., ELF5) or suggestive but unreported (e.g., RAB2A) candidate protein mediators of COVID-19 outcomes by integrating results from the COVID-19 Host Genetics Initiative with population-based plasma proteomics using statistical colocalisation. The transcription factor ELF5 (ELF5) shows robust and directionally consistent associations across different outcome definitions, including a >4-fold higher risk (odds ratio: 4.88; 95%-CI: 2.47–9.63; p-value

Suggested Citation

  • Maik Pietzner & Robert Lorenz Chua & Eleanor Wheeler & Katharina Jechow & Julian D. S. Willett & Helena Radbruch & Saskia Trump & Bettina Heidecker & Hugo Zeberg & Frank L. Heppner & Roland Eils & Mar, 2022. "ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31999-6
    DOI: 10.1038/s41467-022-31999-6
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