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Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair

Author

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  • Makoto Takeo

    (RIKEN Center for Developmental Biology (CDB) and RIKEN Center for Biosystems Dynamics Research (BDR))

  • Koh-ei Toyoshima

    (RIKEN Center for Developmental Biology (CDB) and RIKEN Center for Biosystems Dynamics Research (BDR)
    OrganTech Inc.)

  • Riho Fujimoto

    (Kwansei-Gakuin University)

  • Tomoyo Iga

    (RIKEN Center for Developmental Biology (CDB) and RIKEN Center for Biosystems Dynamics Research (BDR))

  • Miki Takase

    (RIKEN Center for Developmental Biology (CDB) and RIKEN Center for Biosystems Dynamics Research (BDR))

  • Miho Ogawa

    (OrganTech Inc.)

  • Takashi Tsuji

    (RIKEN Center for Developmental Biology (CDB) and RIKEN Center for Biosystems Dynamics Research (BDR)
    OrganTech Inc.)

Abstract

Biological rhythms are involved in almost all types of biological processes, not only physiological processes but also morphogenesis. Currently, how periodic morphological patterns of tissues/organs in multicellular organisms form is not fully understood. Here, using mouse zigzag hair, which has 3 bends, we found that a change in the combination of hair progenitors and their micro-niche and subsequent bend formation occur every three days. Chimeric loss-of-function and gain-of-function of Ptn and Aff3, which are upregulated immediately before bend formation, resulted in defects in the downward movement of the micro-niche and the rhythm of bend formation in an in vivo hair reconstitution assay. Our study demonstrates the periodic change in the combination between progenitors and micro-niche, which is vital for the unique infradian rhythm.

Suggested Citation

  • Makoto Takeo & Koh-ei Toyoshima & Riho Fujimoto & Tomoyo Iga & Miki Takase & Miho Ogawa & Takashi Tsuji, 2023. "Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39605-z
    DOI: 10.1038/s41467-023-39605-z
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    References listed on IDEAS

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    1. Gal Manella & Dan Aizik & Rona Aviram & Marina Golik & Gad Asher, 2021. "Circa-SCOPE: high-throughput live single-cell imaging method for analysis of circadian clock resetting," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Emi K. Nishimura & Siobhán A. Jordan & Hideo Oshima & Hisahiro Yoshida & Masatake Osawa & Mariko Moriyama & Ian J. Jackson & Yann Barrandon & Yoshiki Miyachi & Shin-Ichi Nishikawa, 2002. "Dominant role of the niche in melanocyte stem-cell fate determination," Nature, Nature, vol. 416(6883), pages 854-860, April.
    3. Laila Ritsma & Saskia I. J. Ellenbroek & Anoek Zomer & Hugo J. Snippert & Frederic J. de Sauvage & Benjamin D. Simons & Hans Clevers & Jacco van Rheenen, 2014. "Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging," Nature, Nature, vol. 507(7492), pages 362-365, March.
    4. Koh-ei Toyoshima & Kyosuke Asakawa & Naoko Ishibashi & Hiroshi Toki & Miho Ogawa & Tomoko Hasegawa & Tarou Irié & Tetsuhiko Tachikawa & Akio Sato & Akira Takeda & Takashi Tsuji, 2012. "Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches," Nature Communications, Nature, vol. 3(1), pages 1-12, January.
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