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Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches

Author

Listed:
  • Koh-ei Toyoshima

    (Research Institute for Science and Technology, Tokyo University of Science)

  • Kyosuke Asakawa

    (Graduate School of Industrial Science and Technology, Tokyo University of Science)

  • Naoko Ishibashi

    (Graduate School of Industrial Science and Technology, Tokyo University of Science)

  • Hiroshi Toki

    (Research Institute for Science and Technology, Tokyo University of Science)

  • Miho Ogawa

    (Organ Technologies Inc.)

  • Tomoko Hasegawa

    (Graduate School of Industrial Science and Technology, Tokyo University of Science)

  • Tarou Irié

    (Showa University School of Dentistry)

  • Tetsuhiko Tachikawa

    (Showa University School of Dentistry)

  • Akio Sato

    (Research Institute for Science and Technology, Tokyo University of Science
    Tokyo Memorial Clinic
    Plastic and Reconstructive Surgery, Kitasato University School of Medicine, Sagamihara)

  • Akira Takeda

    (Research Institute for Science and Technology, Tokyo University of Science
    Kitasato University School of Medicine, Sagamihara)

  • Takashi Tsuji

    (Research Institute for Science and Technology, Tokyo University of Science
    Graduate School of Industrial Science and Technology, Tokyo University of Science
    Organ Technologies Inc.)

Abstract

Organ replacement regenerative therapy is purported to enable the replacement of organs damaged by disease, injury or aging in the foreseeable future. Here we demonstrate fully functional hair organ regeneration via the intracutaneous transplantation of a bioengineered pelage and vibrissa follicle germ. The pelage and vibrissae are reconstituted with embryonic skin-derived cells and adult vibrissa stem cell region-derived cells, respectively. The bioengineered hair follicle develops the correct structures and forms proper connections with surrounding host tissues such as the epidermis, arrector pili muscle and nerve fibres. The bioengineered follicles also show restored hair cycles and piloerection through the rearrangement of follicular stem cells and their niches. This study thus reveals the potential applications of adult tissue-derived follicular stem cells as a bioengineered organ replacement therapy.

Suggested Citation

  • Koh-ei Toyoshima & Kyosuke Asakawa & Naoko Ishibashi & Hiroshi Toki & Miho Ogawa & Tomoko Hasegawa & Tarou Irié & Tetsuhiko Tachikawa & Akio Sato & Akira Takeda & Takashi Tsuji, 2012. "Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches," Nature Communications, Nature, vol. 3(1), pages 1-12, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1784
    DOI: 10.1038/ncomms1784
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    Cited by:

    1. Makoto Takeo & Koh-ei Toyoshima & Riho Fujimoto & Tomoyo Iga & Miki Takase & Miho Ogawa & Takashi Tsuji, 2023. "Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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