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Singularity response reveals entrainment properties in mammalian circadian clock

Author

Listed:
  • Kosaku Masuda

    (University of Tsukuba
    University of Tsukuba)

  • Naohiro Kon

    (Nagoya University
    Graduate School of Bioagricultural Sciences, Nagoya University
    Graduate School of Science, The University of Tokyo
    Suntory Rising Stars Encouragement Program in Life Sciences (SunRiSE))

  • Kosuke Iizuka

    (Nagoya University
    Graduate School of Bioagricultural Sciences, Nagoya University)

  • Yoshitaka Fukada

    (Graduate School of Science, The University of Tokyo
    Graduate School of Medicine, The University of Tokyo)

  • Takeshi Sakurai

    (University of Tsukuba
    University of Tsukuba)

  • Arisa Hirano

    (University of Tsukuba
    University of Tsukuba)

Abstract

Entrainment is characterized by phase response curves (PRCs), which provide a summary of responses to perturbations at each circadian phase. The synchronization of mammalian circadian clocks is accomplished through the receipt of a variety of inputs from both internal and external time cues. A comprehensive comparison of PRCs for various stimuli in each tissue is required. Herein, we demonstrate that PRCs in mammalian cells can be characterized using a recently developed estimation method based on singularity response (SR), which represents the response of desynchronized cellular clocks. We confirmed that PRCs can be reconstructed using single SR measurements and quantified response properties for various stimuli in several cell lines. SR analysis reveals that the phase and amplitude after resetting are distinguishable among stimuli. SRs in tissue slice cultures reveal tissue-specific entrainment properties. These results demonstrate that SRs can be employed to unveil entrainment mechanisms with diverse stimuli in multiscale mammalian clocks.

Suggested Citation

  • Kosaku Masuda & Naohiro Kon & Kosuke Iizuka & Yoshitaka Fukada & Takeshi Sakurai & Arisa Hirano, 2023. "Singularity response reveals entrainment properties in mammalian circadian clock," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38392-x
    DOI: 10.1038/s41467-023-38392-x
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    References listed on IDEAS

    as
    1. Victoria A. Acosta-Rodríguez & Filipa Rijo-Ferreira & Carla B. Green & Joseph S. Takahashi, 2021. "Importance of circadian timing for aging and longevity," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Gal Manella & Dan Aizik & Rona Aviram & Marina Golik & Gad Asher, 2021. "Circa-SCOPE: high-throughput live single-cell imaging method for analysis of circadian clock resetting," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Kosaku Masuda & Isao T. Tokuda & Norihito Nakamichi & Hirokazu Fukuda, 2021. "The singularity response reveals entrainment properties of the plant circadian clock," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
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