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Dominant role of the niche in melanocyte stem-cell fate determination

Author

Listed:
  • Emi K. Nishimura

    (Kyoto University
    Harvard Medical School)

  • Siobhán A. Jordan

    (Western General Hospital)

  • Hideo Oshima

    (Ecole Nomale Supérieure
    St Marianna University School of Medicine)

  • Hisahiro Yoshida
  • Masatake Osawa

    (Riken Center for Developmental Biology)

  • Mariko Moriyama

    (Riken Center for Developmental Biology)

  • Ian J. Jackson

    (Western General Hospital)

  • Yann Barrandon

    (Ecole Nomale Supérieure)

  • Yoshiki Miyachi

    (Kyoto University)

  • Shin-Ichi Nishikawa

    (Riken Center for Developmental Biology)

Abstract

Stem cells—which have the capacity to self-renew and generate differentiated progeny—are thought to be maintained in a specific environment known as a niche1,2,3. The localization of the niche, however, remains largely obscure for most stem-cell systems. Melanocytes (pigment cells) in hair follicles proliferate and differentiate closely coupled to the hair regeneration cycle4. Here we report that stem cells of the melanocyte lineage can be identified, using Dct-lacZ transgenic mice5,6, in the lower permanent portion of mouse hair follicles throughout the hair cycle. It is only the population in this region that fulfils the criteria for stem cells, being immature, slow cycling, self-maintaining and fully competent in regenerating progeny on activation at early anagen (the growing phase of hair follicles). Induction of the re-pigmentation process in K14-steel factor transgenic mice7 demonstrates that a portion of amplifying stem-cell progeny can migrate out from the niche and retain sufficient self-renewing capability to function as stem cells after repopulation into vacant niches. Our data indicate that the niche has a dominant role in the fate determination of melanocyte stem-cell progeny.

Suggested Citation

  • Emi K. Nishimura & Siobhán A. Jordan & Hideo Oshima & Hisahiro Yoshida & Masatake Osawa & Mariko Moriyama & Ian J. Jackson & Yann Barrandon & Yoshiki Miyachi & Shin-Ichi Nishikawa, 2002. "Dominant role of the niche in melanocyte stem-cell fate determination," Nature, Nature, vol. 416(6883), pages 854-860, April.
    • Handle: RePEc:nat:nature:v:416:y:2002:i:6883:d:10.1038_416854a
    DOI: 10.1038/416854a
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    Cited by:

    1. Elle Koren & Alona Feldman & Marianna Yusupova & Avihay Kadosh & Egor Sedov & Roi Ankawa & Yahav Yosefzon & Waseem Nasser & Stefanie Gerstberger & Liam B. Kimel & Noa Priselac & Samara Brown & Sam Sha, 2022. "Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Makoto Takeo & Koh-ei Toyoshima & Riho Fujimoto & Tomoyo Iga & Miki Takase & Miho Ogawa & Takashi Tsuji, 2023. "Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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