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Detailed characterization of neural selectivity in free viewing primates

Author

Listed:
  • Jacob L. Yates

    (University of Rochester
    University of Rochester
    University of Maryland
    UC Berkeley)

  • Shanna H. Coop

    (University of Rochester
    University of Rochester
    Stanford University)

  • Gabriel H. Sarch

    (University of Rochester
    Carnegie Mellon University)

  • Ruei-Jr Wu

    (University of Rochester
    University of Rochester)

  • Daniel A. Butts

    (University of Maryland)

  • Michele Rucci

    (University of Rochester
    University of Rochester)

  • Jude F. Mitchell

    (University of Rochester
    University of Rochester)

Abstract

Fixation constraints in visual tasks are ubiquitous in visual and cognitive neuroscience. Despite its widespread use, fixation requires trained subjects, is limited by the accuracy of fixational eye movements, and ignores the role of eye movements in shaping visual input. To overcome these limitations, we developed a suite of hardware and software tools to study vision during natural behavior in untrained subjects. We measured visual receptive fields and tuning properties from multiple cortical areas of marmoset monkeys who freely viewed full-field noise stimuli. The resulting receptive fields and tuning curves from primary visual cortex (V1) and area MT match reported selectivity from the literature which was measured using conventional approaches. We then combined free viewing with high-resolution eye tracking to make the first detailed 2D spatiotemporal measurements of foveal receptive fields in V1. These findings demonstrate the power of free viewing to characterize neural responses in untrained animals while simultaneously studying the dynamics of natural behavior.

Suggested Citation

  • Jacob L. Yates & Shanna H. Coop & Gabriel H. Sarch & Ruei-Jr Wu & Daniel A. Butts & Michele Rucci & Jude F. Mitchell, 2023. "Detailed characterization of neural selectivity in free viewing primates," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38564-9
    DOI: 10.1038/s41467-023-38564-9
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    References listed on IDEAS

    as
    1. Michele A. Basso & Robert H. Wurtz, 1997. "Modulation of neuronal activity by target uncertainty," Nature, Nature, vol. 389(6646), pages 66-69, September.
    2. Enny H. Beest & Sreedeep Mukherjee & Lisa Kirchberger & Ulf H. Schnabel & Chris Togt & Rob R. M. Teeuwen & Areg Barsegyan & Arne F. Meyer & Jasper Poort & Pieter R. Roelfsema & Matthew W. Self, 2021. "Mouse visual cortex contains a region of enhanced spatial resolution," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    3. Janis Intoy & Michele Rucci, 2020. "Finely tuned eye movements enhance visual acuity," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    4. James M. McFarland & Adrian G. Bondy & Bruce G. Cumming & Daniel A. Butts, 2014. "High-resolution eye tracking using V1 neuron activity," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
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