IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-24311-5.html
   My bibliography  Save this article

Mouse visual cortex contains a region of enhanced spatial resolution

Author

Listed:
  • Enny H. Beest

    (Netherlands Institute for Neuroscience)

  • Sreedeep Mukherjee

    (Netherlands Institute for Neuroscience)

  • Lisa Kirchberger

    (Netherlands Institute for Neuroscience)

  • Ulf H. Schnabel

    (Netherlands Institute for Neuroscience)

  • Chris Togt

    (Netherlands Institute for Neuroscience)

  • Rob R. M. Teeuwen

    (Netherlands Institute for Neuroscience)

  • Areg Barsegyan

    (Netherlands Institute for Neuroscience)

  • Arne F. Meyer

    (Radboud University
    University College London)

  • Jasper Poort

    (University of Cambridge
    University of Cambridge)

  • Pieter R. Roelfsema

    (Netherlands Institute for Neuroscience
    VU University
    Academic Medical Center)

  • Matthew W. Self

    (Netherlands Institute for Neuroscience)

Abstract

The representation of space in mouse visual cortex was thought to be relatively uniform. Here we reveal, using population receptive-field (pRF) mapping techniques, that mouse visual cortex contains a region in which pRFs are considerably smaller. This region, the “focea,” represents a location in space in front of, and slightly above, the mouse. Using two-photon imaging we show that the smaller pRFs are due to lower scatter of receptive-fields at the focea and an over-representation of binocular regions of space. We show that receptive-fields of single-neurons in areas LM and AL are smaller at the focea and that mice have improved visual resolution in this region of space. Furthermore, freely moving mice make compensatory eye-movements to hold this region in front of them. Our results indicate that mice have spatial biases in their visual processing, a finding that has important implications for the use of the mouse model of vision.

Suggested Citation

  • Enny H. Beest & Sreedeep Mukherjee & Lisa Kirchberger & Ulf H. Schnabel & Chris Togt & Rob R. M. Teeuwen & Areg Barsegyan & Arne F. Meyer & Jasper Poort & Pieter R. Roelfsema & Matthew W. Self, 2021. "Mouse visual cortex contains a region of enhanced spatial resolution," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24311-5
    DOI: 10.1038/s41467-021-24311-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-24311-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-24311-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jacob L. Yates & Shanna H. Coop & Gabriel H. Sarch & Ruei-Jr Wu & Daniel A. Butts & Michele Rucci & Jude F. Mitchell, 2023. "Detailed characterization of neural selectivity in free viewing primates," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24311-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.