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Importance of circadian timing for aging and longevity

Author

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  • Victoria A. Acosta-Rodríguez

    (University of Texas Southwestern Medical Center)

  • Filipa Rijo-Ferreira

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Carla B. Green

    (University of Texas Southwestern Medical Center)

  • Joseph S. Takahashi

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

Abstract

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR can be achieved by controlling how much and/or when food is provided, as well as by adjusting nutritional composition. Because these factors are often combined during DR, it is unclear which are necessary for beneficial effects. Several drugs have been utilized that target nutrient-sensing gene pathways, many of which change expression throughout the day, suggesting that the timing of drug administration is critical. Here, we discuss how dietary and pharmacological interventions promote a healthy lifespan by influencing energy intake and circadian rhythms.

Suggested Citation

  • Victoria A. Acosta-Rodríguez & Filipa Rijo-Ferreira & Carla B. Green & Joseph S. Takahashi, 2021. "Importance of circadian timing for aging and longevity," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22922-6
    DOI: 10.1038/s41467-021-22922-6
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    Cited by:

    1. Hongliang Feng & Lulu Yang & Yannis Yan Liang & Sizhi Ai & Yaping Liu & Yue Liu & Xinyi Jin & Binbin Lei & Jing Wang & Nana Zheng & Xinru Chen & Joey W. Y. Chan & Raymond Kim Wai Sum & Ngan Yin Chan &, 2023. "Associations of timing of physical activity with all-cause and cause-specific mortality in a prospective cohort study," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Kosaku Masuda & Naohiro Kon & Kosuke Iizuka & Yoshitaka Fukada & Takeshi Sakurai & Arisa Hirano, 2023. "Singularity response reveals entrainment properties in mammalian circadian clock," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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