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Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives

Author

Listed:
  • Bei Huang

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Steven W. H. Chau

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Yaping Liu

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Affiliated Brain Hospital of Guangzhou Medical University)

  • Joey W. Y. Chan

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Jing Wang

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Affiliated Brain Hospital of Guangzhou Medical University)

  • Suk Ling Ma

    (The Chinese University of Hong Kong)

  • Jihui Zhang

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Affiliated Brain Hospital of Guangzhou Medical University)

  • Paul K. S. Chan

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Yun Kit Yeoh

    (The Chinese University of Hong Kong)

  • Zigui Chen

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Li Zhou

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Sunny Hei Wong

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    Nanyang Technological University)

  • Vincent C. T. Mok

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Ka Fai To

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Hei Ming Lai

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Simon Ng

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Claudia Trenkwalder

    (University Medical Center, Georg August University Göttingen
    Paracelsus-Elena Hospital)

  • Francis K. L. Chan

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

  • Yun Kwok Wing

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Chinese University of Hong Kong)

Abstract

The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD. We show gut microbiota compositions are significantly altered in early PD and RBD compared with control and RBD-FDR. Depletion of butyrate-producing bacteria and enrichment of pro-inflammatory Collinsella have already emerged in RBD and RBD-FDR after controlling potential confounders including antidepressants, osmotic laxatives, and bowel movement frequency. Random forest modelling identifies 12 microbial markers that are effective to distinguish RBD from control. These findings suggest that PD-like gut dysbiosis occurs at the prodromal stages of PD when RBD develops and starts to emerge in the younger RBD-FDR subjects. The study will have etiological and diagnostic implications.

Suggested Citation

  • Bei Huang & Steven W. H. Chau & Yaping Liu & Joey W. Y. Chan & Jing Wang & Suk Ling Ma & Jihui Zhang & Paul K. S. Chan & Yun Kit Yeoh & Zigui Chen & Li Zhou & Sunny Hei Wong & Vincent C. T. Mok & Ka F, 2023. "Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38248-4
    DOI: 10.1038/s41467-023-38248-4
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    References listed on IDEAS

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    1. Himel Mallick & Ali Rahnavard & Lauren J McIver & Siyuan Ma & Yancong Zhang & Long H Nguyen & Timothy L Tickle & George Weingart & Boyu Ren & Emma H Schwager & Suvo Chatterjee & Kelsey N Thompson & Je, 2021. "Multivariable association discovery in population-scale meta-omics studies," PLOS Computational Biology, Public Library of Science, vol. 17(11), pages 1-27, November.
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