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Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy

Author

Listed:
  • Seong Beom An

    (Pohang University of Science and Technology (POSTECH)
    Pohang University of Science and Technology (POSTECH))

  • Bo-Gie Yang

    (Research Institute, GI Innovation Inc., Songpa
    Research Institute, GI Biome Inc.)

  • Gyeonghui Jang

    (Research Institute, GI Innovation Inc., Songpa)

  • Do-Yeon Kim

    (Research Institute, GI Innovation Inc., Songpa)

  • Jiyoung Kim

    (Research Institute, GI Innovation Inc., Songpa)

  • Sung-Man Oh

    (Research Institute, GI Innovation Inc., Songpa)

  • Nahyun Oh

    (Research Institute, GI Innovation Inc., Songpa)

  • Sanghee Lee

    (Research Institute, GI Innovation Inc., Songpa)

  • Ji-Yeong Moon

    (Ajou University School of Medicine)

  • Jeong-Ah Kim

    (Research Institute, GI Innovation Inc., Songpa)

  • Ji-Hyun Kim

    (Research Institute, GI Innovation Inc., Songpa)

  • Yoo-Jeong Song

    (Research Institute, GI Innovation Inc., Songpa)

  • Hye-Won Hyun

    (Research Institute, GI Innovation Inc., Songpa)

  • Jisoo Kim

    (Research Institute, GI Innovation Inc., Songpa)

  • Kyungwha Lee

    (Research Institute, GI Innovation Inc., Songpa)

  • Dajeong Lee

    (Research Institute, GI Biome Inc.)

  • Min-Jung Kwak

    (Research Institute, GI Biome Inc.)

  • Byung Kwon Kim

    (Research Institute, GI Biome Inc.)

  • Young-Kyu Park

    (Research Institute, GI Biome Inc.)

  • Chun-Pyo Hong

    (Research Institute, GI Innovation Inc., Songpa
    GI Cell Inc.)

  • Jung Hwan Kim

    (ProGen Inc.)

  • Hye Seong Lim

    (ProGen Inc.)

  • Min Sook Ryu

    (Ajou University School of Medicine)

  • Hyun-Tak Jin

    (ProGen Inc.)

  • Seung-Woo Lee

    (Pohang University of Science and Technology (POSTECH)
    Pohang University of Science and Technology (POSTECH))

  • Yoon-Seok Chang

    (Seoul National University Bundang Hospital, Seoul National University College of Medicine)

  • Hae-Sim Park

    (Ajou University School of Medicine)

  • Young Chul Sung

    (Pohang University of Science and Technology (POSTECH)
    Pohang University of Science and Technology (POSTECH))

  • Myoung Ho Jang

    (Research Institute, GI Innovation Inc., Songpa
    Osaka University)

Abstract

IgE is central to the development of allergic diseases, and its neutralization alleviates allergic symptoms. However, most of these antibodies are based on IgG1, which is associated with an increased risk of fragment crystallizable-mediated side effects. Moreover, omalizumab, an anti-IgE antibody approved for therapeutic use, has limited benefits for patients with high IgE levels. Here, we assess a fusion protein with extracellular domain of high affinity IgE receptor, FcεRIα, linked to a IgD/IgG4 hybrid Fc domain we term IgETRAP, to reduce the risk of IgG1 Fc-mediated side effects. IgETRAP shows enhanced IgE binding affinity compared to omalizumab. We also see an enhanced therapeutic effect of IgETRAP in food allergy models when combined with Bifidobacterium longum, which results in mast cell number and free IgE levels. The combination of IgETRAP and B. longum may therefore represent a potent treatment for allergic patients with high IgE levels.

Suggested Citation

  • Seong Beom An & Bo-Gie Yang & Gyeonghui Jang & Do-Yeon Kim & Jiyoung Kim & Sung-Man Oh & Nahyun Oh & Sanghee Lee & Ji-Yeong Moon & Jeong-Ah Kim & Ji-Hyun Kim & Yoo-Jeong Song & Hye-Won Hyun & Jisoo Ki, 2022. "Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33176-1
    DOI: 10.1038/s41467-022-33176-1
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    References listed on IDEAS

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    1. Himel Mallick & Ali Rahnavard & Lauren J McIver & Siyuan Ma & Yancong Zhang & Long H Nguyen & Timothy L Tickle & George Weingart & Boyu Ren & Emma H Schwager & Suvo Chatterjee & Kelsey N Thompson & Je, 2021. "Multivariable association discovery in population-scale meta-omics studies," PLOS Computational Biology, Public Library of Science, vol. 17(11), pages 1-27, November.
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