IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-34862-w.html
   My bibliography  Save this article

Impact of international travel and diarrhea on gut microbiome and resistome dynamics

Author

Listed:
  • Manish Boolchandani

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Kevin S. Blake

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Drake H. Tilley

    (Naval Medical Research Unit No. 6, Callao)

  • Miguel M. Cabada

    (University of Texas Medical Branch
    Universidad Peruana Cayetano Heredia)

  • Drew J. Schwartz

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine
    Washington University in St. Louis)

  • Sanket Patel

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Maria Luisa Morales

    (Universidad Peruana Cayetano Heredia)

  • Rina Meza

    (Naval Medical Research Unit No. 6, Callao)

  • Giselle Soto

    (Naval Medical Research Unit No. 6, Callao)

  • Sandra D. Isidean

    (Naval Medical Research Center
    Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc)

  • Chad K. Porter

    (Naval Medical Research Center)

  • Mark P. Simons

    (Naval Medical Research Unit No. 6, Callao
    Naval Medical Research Center)

  • Gautam Dantas

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine
    Washington University in St. Louis)

Abstract

International travel contributes to the global spread of antimicrobial resistance. Travelers’ diarrhea exacerbates the risk of acquiring multidrug-resistant organisms and can lead to persistent gastrointestinal disturbance post-travel. However, little is known about the impact of diarrhea on travelers’ gut microbiomes, and the dynamics of these changes throughout travel. Here, we assembled a cohort of 159 international students visiting the Andean city of Cusco, Peru and applied next-generation sequencing techniques to 718 longitudinally-collected stool samples. We find that gut microbiome composition changed significantly throughout travel, but taxonomic diversity remained stable. However, diarrhea disrupted this stability and resulted in an increased abundance of antimicrobial resistance genes that can remain high for weeks. We also identified taxa differentially abundant between diarrheal and non-diarrheal samples, which were used to develop a classification model that distinguishes between these disease states. Additionally, we sequenced the genomes of 212 diarrheagenic Escherichia coli isolates and found those from travelers who experienced diarrhea encoded more antimicrobial resistance genes than those who did not. In this work, we find the gut microbiomes of international travelers’ are resilient to dysbiosis; however, they are also susceptible to colonization by multidrug-resistant bacteria, a risk that is more pronounced in travelers with diarrhea.

Suggested Citation

  • Manish Boolchandani & Kevin S. Blake & Drake H. Tilley & Miguel M. Cabada & Drew J. Schwartz & Sanket Patel & Maria Luisa Morales & Rina Meza & Giselle Soto & Sandra D. Isidean & Chad K. Porter & Mark, 2022. "Impact of international travel and diarrhea on gut microbiome and resistome dynamics," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34862-w
    DOI: 10.1038/s41467-022-34862-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-34862-w
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-022-34862-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Himel Mallick & Ali Rahnavard & Lauren J McIver & Siyuan Ma & Yancong Zhang & Long H Nguyen & Timothy L Tickle & George Weingart & Boyu Ren & Emma H Schwager & Suvo Chatterjee & Kelsey N Thompson & Je, 2021. "Multivariable association discovery in population-scale meta-omics studies," PLOS Computational Biology, Public Library of Science, vol. 17(11), pages 1-27, November.
    2. Kevin J. Forsberg & Sanket Patel & Molly K. Gibson & Christian L. Lauber & Rob Knight & Noah Fierer & Gautam Dantas, 2014. "Bacterial phylogeny structures soil resistomes across habitats," Nature, Nature, vol. 509(7502), pages 612-616, May.
    3. Daphna Rothschild & Omer Weissbrod & Elad Barkan & Alexander Kurilshikov & Tal Korem & David Zeevi & Paul I. Costea & Anastasia Godneva & Iris N. Kalka & Noam Bar & Smadar Shilo & Dar Lador & Arnau Vi, 2018. "Environment dominates over host genetics in shaping human gut microbiota," Nature, Nature, vol. 555(7695), pages 210-215, March.
    4. Erica C. Pehrsson & Pablo Tsukayama & Sanket Patel & Melissa Mejía-Bautista & Giordano Sosa-Soto & Karla M. Navarrete & Maritza Calderon & Lilia Cabrera & William Hoyos-Arango & M. Teresita Bertoli & , 2016. "Interconnected microbiomes and resistomes in low-income human habitats," Nature, Nature, vol. 533(7602), pages 212-216, May.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Victoria T. Chu & Alexandra Tsitsiklis & Eran Mick & Lilliam Ambroggio & Katrina L. Kalantar & Abigail Glascock & Christina M. Osborne & Brandie D. Wagner & Michael A. Matthay & Joseph L. DeRisi & Car, 2024. "The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Andrea Quagliariello & Alessandra Modi & Gabriel Innocenti & Valentina Zaro & Cecilia Conati Barbaro & Annamaria Ronchitelli & Francesco Boschin & Claudio Cavazzuti & Elena Dellù & Francesca Radina & , 2022. "Ancient oral microbiomes support gradual Neolithic dietary shifts towards agriculture," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Zhirui Cao & Dejun Fan & Yang Sun & Ziyu Huang & Yue Li & Runping Su & Feng Zhang & Qing Li & Hongju Yang & Fen Zhang & Yinglei Miao & Ping Lan & Xiaojian Wu & Tao Zuo, 2024. "The gut ileal mucosal virome is disturbed in patients with Crohn’s disease and exacerbates intestinal inflammation in mice," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    3. Jos A. Bosch & Max Nieuwdorp & Aeilko H. Zwinderman & Mélanie Deschasaux & Djawad Radjabzadeh & Robert Kraaij & Mark Davids & Susanne R. Rooij & Anja Lok, 2022. "The gut microbiota and depressive symptoms across ethnic groups," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Qinnan Yang & Mallory Haute & Nate Korth & Scott E. Sattler & John Toy & Devin J. Rose & James C. Schnable & Andrew K. Benson, 2022. "Genetic analysis of seed traits in Sorghum bicolor that affect the human gut microbiome," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Fanette Fontaine & Sondra Turjeman & Karel Callens & Omry Koren, 2023. "The intersection of undernutrition, microbiome, and child development in the first years of life," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    6. Na Li & Chong Liu & Zhiguo Zhang & Hongna Li & Tingting Song & Ting Liang & Binxu Li & Luyao Li & Shuo Feng & Qianqian Su & Jing Ye & Changxiong Zhu, 2019. "Research and Technological Advances Regarding the Study of the Spread of Antimicrobial Resistance Genes and Antimicrobial-Resistant Bacteria Related to Animal Husbandry," IJERPH, MDPI, vol. 16(24), pages 1-19, December.
    7. Kerstin Thriene & Karin B. Michels, 2023. "Human Gut Microbiota Plasticity throughout the Life Course," IJERPH, MDPI, vol. 20(2), pages 1-14, January.
    8. Patrick Munk & Christian Brinch & Frederik Duus Møller & Thomas N. Petersen & Rene S. Hendriksen & Anne Mette Seyfarth & Jette S. Kjeldgaard & Christina Aaby Svendsen & Bram Bunnik & Fanny Berglund & , 2022. "Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    9. Bo Tang & Li Tang & Shengpeng Li & Shuang Liu & Jialin He & Pan Li & Sumin Wang & Min Yang & Longhui Zhang & Yuanyuan Lei & Dianji Tu & Xuefeng Tang & Hua Hu & Qin Ouyang & Xia Chen & Shiming Yang, 2023. "Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    10. Lingling Wang & Haobin Yao & Daniel C. Morgan & Kam Shing Lau & Suet Yi Leung & Joshua W. K. Ho & Wai K. Leung, 2023. "Altered human gut virome in patients undergoing antibiotics therapy for Helicobacter pylori," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    11. Carolina Alves Costa Silva & Gianmarco Piccinno & Déborah Suissa & Mélanie Bourgin & Gerty Schreibelt & Sylvère Durand & Roxanne Birebent & Marine Fidelle & Cissé Sow & Fanny Aprahamian & Paolo Manghi, 2024. "Influence of microbiota-associated metabolic reprogramming on clinical outcome in patients with melanoma from the randomized adjuvant dendritic cell-based MIND-DC trial," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    12. Lharbi Dridi & Fernando Altamura & Emmanuel Gonzalez & Olivia Lui & Ryszard Kubinski & Reilly Pidgeon & Adrian Montagut & Jasmine Chong & Jianguo Xia & Corinne F. Maurice & Bastien Castagner, 2023. "Identifying glycan consumers in human gut microbiota samples using metabolic labeling coupled with fluorescence-activated cell sorting," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    13. Andrew Baldi & Sabine Braat & Mohammed Imrul Hasan & Cavan Bennett & Marilou Barrios & Naomi Jones & Gemma Moir-Meyer & Imadh Abdul Azeez & Stephen Wilcox & Mohammad Saiful Alam Bhuiyan & Ricardo Atai, 2024. "Community use of oral antibiotics transiently reprofiles the intestinal microbiome in young Bangladeshi children," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    14. M. Büttner & J. Ostner & C. L. Müller & F. J. Theis & B. Schubert, 2021. "scCODA is a Bayesian model for compositional single-cell data analysis," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    15. Seong Beom An & Bo-Gie Yang & Gyeonghui Jang & Do-Yeon Kim & Jiyoung Kim & Sung-Man Oh & Nahyun Oh & Sanghee Lee & Ji-Yeong Moon & Jeong-Ah Kim & Ji-Hyun Kim & Yoo-Jeong Song & Hye-Won Hyun & Jisoo Ki, 2022. "Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    16. Xuanji Li & Asker Brejnrod & Jonathan Thorsen & Trine Zachariasen & Urvish Trivedi & Jakob Russel & Gisle Alberg Vestergaard & Jakob Stokholm & Morten Arendt Rasmussen & Søren Johannes Sørensen, 2023. "Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    17. Jun Ueyama & Mai Hayashi & Masaaki Hirayama & Hiroshi Nishiwaki & Mikako Ito & Isao Saito & Yoshio Tsuboi & Tomohiko Isobe & Kinji Ohno, 2022. "Effects of Pesticide Intake on Gut Microbiota and Metabolites in Healthy Adults," IJERPH, MDPI, vol. 20(1), pages 1-13, December.
    18. Fiona B. Tamburini & Dylan Maghini & Ovokeraye H. Oduaran & Ryan Brewster & Michaella R. Hulley & Venesa Sahibdeen & Shane A. Norris & Stephen Tollman & Kathleen Kahn & Ryan G. Wagner & Alisha N. Wade, 2022. "Short- and long-read metagenomics of urban and rural South African gut microbiomes reveal a transitional composition and undescribed taxa," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    19. Aarthi Ravikrishnan & Indrik Wijaya & Eileen Png & Kern Rei Chng & Eliza Xin Pei Ho & Amanda Hui Qi Ng & Ahmad Nazri Mohamed Naim & Jean-Sebastien Gounot & Shou Ping Guan & Jasinda Lee Hanqing & Lihua, 2024. "Gut metagenomes of Asian octogenarians reveal metabolic potential expansion and distinct microbial species associated with aging phenotypes," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    20. Naven Ramdat & Zi-Jing Wang & Jung-Chen Huang & Yikun Wang & Azharuddin Chachar & Chuanqi Zhou & Zhiping Wang, 2022. "Effects of Enrofloxacin on Nutrient Removal by a Floating Treatment Wetland Planted with Iris pseudacorus : Response and Resilience of Rhizosphere Microbial Communities," Sustainability, MDPI, vol. 14(6), pages 1-18, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34862-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.