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Impact of international travel and diarrhea on gut microbiome and resistome dynamics

Author

Listed:
  • Manish Boolchandani

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Kevin S. Blake

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Drake H. Tilley

    (Naval Medical Research Unit No. 6, Callao)

  • Miguel M. Cabada

    (University of Texas Medical Branch
    Universidad Peruana Cayetano Heredia)

  • Drew J. Schwartz

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine
    Washington University in St. Louis)

  • Sanket Patel

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Maria Luisa Morales

    (Universidad Peruana Cayetano Heredia)

  • Rina Meza

    (Naval Medical Research Unit No. 6, Callao)

  • Giselle Soto

    (Naval Medical Research Unit No. 6, Callao)

  • Sandra D. Isidean

    (Naval Medical Research Center
    Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc)

  • Chad K. Porter

    (Naval Medical Research Center)

  • Mark P. Simons

    (Naval Medical Research Unit No. 6, Callao
    Naval Medical Research Center)

  • Gautam Dantas

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine
    Washington University in St. Louis)

Abstract

International travel contributes to the global spread of antimicrobial resistance. Travelers’ diarrhea exacerbates the risk of acquiring multidrug-resistant organisms and can lead to persistent gastrointestinal disturbance post-travel. However, little is known about the impact of diarrhea on travelers’ gut microbiomes, and the dynamics of these changes throughout travel. Here, we assembled a cohort of 159 international students visiting the Andean city of Cusco, Peru and applied next-generation sequencing techniques to 718 longitudinally-collected stool samples. We find that gut microbiome composition changed significantly throughout travel, but taxonomic diversity remained stable. However, diarrhea disrupted this stability and resulted in an increased abundance of antimicrobial resistance genes that can remain high for weeks. We also identified taxa differentially abundant between diarrheal and non-diarrheal samples, which were used to develop a classification model that distinguishes between these disease states. Additionally, we sequenced the genomes of 212 diarrheagenic Escherichia coli isolates and found those from travelers who experienced diarrhea encoded more antimicrobial resistance genes than those who did not. In this work, we find the gut microbiomes of international travelers’ are resilient to dysbiosis; however, they are also susceptible to colonization by multidrug-resistant bacteria, a risk that is more pronounced in travelers with diarrhea.

Suggested Citation

  • Manish Boolchandani & Kevin S. Blake & Drake H. Tilley & Miguel M. Cabada & Drew J. Schwartz & Sanket Patel & Maria Luisa Morales & Rina Meza & Giselle Soto & Sandra D. Isidean & Chad K. Porter & Mark, 2022. "Impact of international travel and diarrhea on gut microbiome and resistome dynamics," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34862-w
    DOI: 10.1038/s41467-022-34862-w
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    1. Victoria T. Chu & Alexandra Tsitsiklis & Eran Mick & Lilliam Ambroggio & Katrina L. Kalantar & Abigail Glascock & Christina M. Osborne & Brandie D. Wagner & Michael A. Matthay & Joseph L. DeRisi & Car, 2024. "The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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