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Single-neuron mechanisms of neural adaptation in the human temporal lobe

Author

Listed:
  • Thomas P. Reber

    (UniDistance Suisse
    University of Bonn Medical Centre)

  • Sina Mackay

    (University of Bonn Medical Centre)

  • Marcel Bausch

    (University of Bonn Medical Centre)

  • Marcel S. Kehl

    (University of Bonn Medical Centre)

  • Valeri Borger

    (University of Bonn Medical Centre)

  • Rainer Surges

    (University of Bonn Medical Centre)

  • Florian Mormann

    (University of Bonn Medical Centre)

Abstract

A central function of the human brain is to adapt to new situations based on past experience. Adaptation is reflected behaviorally by shorter reaction times to repeating or similar stimuli, and neurophysiologically by reduced neural activity in bulk-tissue measurements with fMRI or EEG. Several potential single-neuron mechanisms have been hypothesized to cause this reduction of activity at the macroscopic level. We here explore these mechanisms using an adaptation paradigm with visual stimuli bearing abstract semantic similarity. We recorded intracranial EEG (iEEG) simultaneously with spiking activity of single neurons in the medial temporal lobes of 25 neurosurgical patients. Recording from 4917 single neurons, we demonstrate that reduced event-related potentials in the macroscopic iEEG signal are associated with a sharpening of single-neuron tuning curves in the amygdala, but with an overall reduction of single-neuron activity in the hippocampus, entorhinal cortex, and parahippocampal cortex, consistent with fatiguing in these areas.

Suggested Citation

  • Thomas P. Reber & Sina Mackay & Marcel Bausch & Marcel S. Kehl & Valeri Borger & Rainer Surges & Florian Mormann, 2023. "Single-neuron mechanisms of neural adaptation in the human temporal lobe," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38190-5
    DOI: 10.1038/s41467-023-38190-5
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    References listed on IDEAS

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