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Oncogenic drivers dictate immune control of acute myeloid leukemia

Author

Listed:
  • Rebecca J. Austin

    (QIMR Berghofer Medical Research Institute
    The University of Queensland, St Lucia
    NYU Grossman School of Medicine
    Laura & Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine)

  • Jasmin Straube

    (QIMR Berghofer Medical Research Institute
    The University of Queensland, St Lucia)

  • Rohit Halder

    (QIMR Berghofer Medical Research Institute)

  • Yashaswini Janardhanan

    (QIMR Berghofer Medical Research Institute)

  • Claudia Bruedigam

    (QIMR Berghofer Medical Research Institute
    The University of Queensland, St Lucia)

  • Matthew Witkowski

    (NYU Grossman School of Medicine
    Laura & Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine
    University of Colorado Anschutz Medical Campus)

  • Leanne Cooper

    (QIMR Berghofer Medical Research Institute)

  • Amy Porter

    (QIMR Berghofer Medical Research Institute)

  • Matthias Braun

    (QIMR Berghofer Medical Research Institute)

  • Fernando Souza-Fonseca-Guimaraes

    (The University of Queensland)

  • Simone A. Minnie

    (QIMR Berghofer Medical Research Institute
    Fred Hutchinson Cancer Centre, Seattle Cancer Care Alliance)

  • Emily Cooper

    (QIMR Berghofer Medical Research Institute)

  • Sebastien Jacquelin

    (QIMR Berghofer Medical Research Institute
    The University of Queensland)

  • Axia Song

    (QIMR Berghofer Medical Research Institute)

  • Tobias Bald

    (QIMR Berghofer Medical Research Institute
    University Hospital of Bonn)

  • Kyohei Nakamura

    (QIMR Berghofer Medical Research Institute)

  • Geoffrey R. Hill

    (QIMR Berghofer Medical Research Institute
    Fred Hutchinson Cancer Centre, Seattle Cancer Care Alliance)

  • Iannis Aifantis

    (NYU Grossman School of Medicine
    Laura & Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine)

  • Steven W. Lane

    (QIMR Berghofer Medical Research Institute
    The University of Queensland, St Lucia
    Royal Brisbane and Women’s Hospital)

  • Megan J. Bywater

    (QIMR Berghofer Medical Research Institute
    The University of Queensland, St Lucia)

Abstract

Acute myeloid leukemia (AML) is a genetically heterogeneous, aggressive hematological malignancy induced by distinct oncogenic driver mutations. The effect of specific AML oncogenes on immune activation or suppression is unclear. Here, we examine immune responses in genetically distinct models of AML and demonstrate that specific AML oncogenes dictate immunogenicity, the quality of immune response and immune escape through immunoediting. Specifically, expression of NrasG12D alone is sufficient to drive a potent anti-leukemia response through increased MHC Class II expression that can be overcome with increased expression of Myc. These data have important implications for the design and implementation of personalized immunotherapies for patients with AML.

Suggested Citation

  • Rebecca J. Austin & Jasmin Straube & Rohit Halder & Yashaswini Janardhanan & Claudia Bruedigam & Matthew Witkowski & Leanne Cooper & Amy Porter & Matthias Braun & Fernando Souza-Fonseca-Guimaraes & Si, 2023. "Oncogenic drivers dictate immune control of acute myeloid leukemia," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37592-9
    DOI: 10.1038/s41467-023-37592-9
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    References listed on IDEAS

    as
    1. Megan J. Bywater & Deborah L. Burkhart & Jasmin Straube & Arianna Sabò & Vera Pendino & James E. Hudson & Gregory A. Quaife-Ryan & Enzo R. Porrello & James Rae & Robert G. Parton & Theresia R. Kress &, 2020. "Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    2. Kazuyoshi Takeda & Masafumi Nakayama & Yoshihiro Hayakawa & Yuko Kojima & Hiroaki Ikeda & Naoko Imai & Kouetsu Ogasawara & Ko Okumura & David M. Thomas & Mark J. Smyth, 2017. "IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting," Nature Communications, Nature, vol. 8(1), pages 1-13, April.
    3. Hirokazu Matsushita & Matthew D. Vesely & Daniel C. Koboldt & Charles G. Rickert & Ravindra Uppaluri & Vincent J. Magrini & Cora D. Arthur & J. Michael White & Yee-Shiuan Chen & Lauren K. Shea & Jasre, 2012. "Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting," Nature, Nature, vol. 482(7385), pages 400-404, February.
    4. Michel DuPage & Claire Mazumdar & Leah M. Schmidt & Ann F. Cheung & Tyler Jacks, 2012. "Expression of tumour-specific antigens underlies cancer immunoediting," Nature, Nature, vol. 482(7385), pages 405-409, February.
    5. Dario Zimmerli & Chiara S. Brambillasca & Francien Talens & Jinhyuk Bhin & Renske Linstra & Lou Romanens & Arkajyoti Bhattacharya & Stacey E. P. Joosten & Ana Moises Silva & Nuno Padrao & Max D. Welle, 2022. "MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    6. Ludmil B. Alexandrov & Serena Nik-Zainal & David C. Wedge & Samuel A. J. R. Aparicio & Sam Behjati & Andrew V. Biankin & Graham R. Bignell & Niccolò Bolli & Ake Borg & Anne-Lise Børresen-Dale & Sandri, 2013. "Correction: Corrigendum: Signatures of mutational processes in human cancer," Nature, Nature, vol. 502(7470), pages 258-258, October.
    7. Ludmil B. Alexandrov & Serena Nik-Zainal & David C. Wedge & Samuel A. J. R. Aparicio & Sam Behjati & Andrew V. Biankin & Graham R. Bignell & Niccolò Bolli & Ake Borg & Anne-Lise Børresen-Dale & Sandri, 2013. "Signatures of mutational processes in human cancer," Nature, Nature, vol. 500(7463), pages 415-421, August.
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