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Expression of tumour-specific antigens underlies cancer immunoediting

Author

Listed:
  • Michel DuPage

    (Massachusetts Institute of Technology)

  • Claire Mazumdar

    (Massachusetts Institute of Technology)

  • Leah M. Schmidt

    (Massachusetts Institute of Technology)

  • Ann F. Cheung

    (Massachusetts Institute of Technology)

  • Tyler Jacks

    (Massachusetts Institute of Technology
    Howard Hughes Medical Institute, Massachusetts Institute of Technology)

Abstract

This paper illustrates that immunosurveillance and immunoediting can occur in an oncogene-driven endogenous tumour model provided that the tumours carry strong neoantigens not present in the host.

Suggested Citation

  • Michel DuPage & Claire Mazumdar & Leah M. Schmidt & Ann F. Cheung & Tyler Jacks, 2012. "Expression of tumour-specific antigens underlies cancer immunoediting," Nature, Nature, vol. 482(7385), pages 405-409, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7385:d:10.1038_nature10803
    DOI: 10.1038/nature10803
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    Cited by:

    1. Julie M. Mazet & Jagdish N. Mahale & Orion Tong & Robert A. Watson & Ana Victoria Lechuga‐Vieco & Gabriela Pirgova & Vivian W. C. Lau & Moustafa Attar & Lada A. Koneva & Stephen N. Sansom & Benjamin P, 2023. "IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Rebecca J. Austin & Jasmin Straube & Rohit Halder & Yashaswini Janardhanan & Claudia Bruedigam & Matthew Witkowski & Leanne Cooper & Amy Porter & Matthias Braun & Fernando Souza-Fonseca-Guimaraes & Si, 2023. "Oncogenic drivers dictate immune control of acute myeloid leukemia," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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