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Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

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  • Hirokazu Matsushita

    (Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Present address: Department of Immunotherapeutics (Medinet), The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.)

  • Matthew D. Vesely

    (Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Daniel C. Koboldt

    (The Genome Institute, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Charles G. Rickert

    (Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Ravindra Uppaluri

    (Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Vincent J. Magrini

    (The Genome Institute, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Cora D. Arthur

    (Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • J. Michael White

    (Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Yee-Shiuan Chen

    (Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Lauren K. Shea

    (Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Jasreet Hundal

    (The Genome Institute, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Michael C. Wendl

    (The Genome Institute, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Ryan Demeter

    (The Genome Institute, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Todd Wylie

    (The Genome Institute, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • James P. Allison

    (Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center
    Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center)

  • Mark J. Smyth

    (Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, 3002 Victoria, Australia
    University of Melbourne, Parkville, 2010 Victoria, Australia)

  • Lloyd J. Old

    (New York Branch of The Ludwig Institute for Cancer Research at Memorial Sloan-Kettering Cancer Center)

  • Elaine R. Mardis

    (The Genome Institute, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

  • Robert D. Schreiber

    (Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA)

Abstract

Exome analysis of chemical-carcinogen-induced mouse tumours provides evidence for T-cell-mediated immunoselection as a mechanism of immunoediting.

Suggested Citation

  • Hirokazu Matsushita & Matthew D. Vesely & Daniel C. Koboldt & Charles G. Rickert & Ravindra Uppaluri & Vincent J. Magrini & Cora D. Arthur & J. Michael White & Yee-Shiuan Chen & Lauren K. Shea & Jasre, 2012. "Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting," Nature, Nature, vol. 482(7385), pages 400-404, February.
    • Handle: RePEc:nat:nature:v:482:y:2012:i:7385:d:10.1038_nature10755
    DOI: 10.1038/nature10755
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    Cited by:

    1. Louise A. Baldwin & Nenad Bartonicek & Jessica Yang & Sunny Z. Wu & Niantao Deng & Daniel L. Roden & Chia-Ling Chan & Ghamdan Al-Eryani & Damien J. Zanker & Belinda S. Parker & Alexander Swarbrick & S, 2022. "DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and immunotherapy response," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Rebecca J. Austin & Jasmin Straube & Rohit Halder & Yashaswini Janardhanan & Claudia Bruedigam & Matthew Witkowski & Leanne Cooper & Amy Porter & Matthias Braun & Fernando Souza-Fonseca-Guimaraes & Si, 2023. "Oncogenic drivers dictate immune control of acute myeloid leukemia," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. John P. Finnigan & Jenna H. Newman & Yury Patskovsky & Larysa Patskovska & Andrew S. Ishizuka & Geoffrey M. Lynn & Robert A. Seder & Michelle Krogsgaard & Nina Bhardwaj, 2024. "Structural basis for self-discrimination by neoantigen-specific TCRs," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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