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Clinical and genomic features of Chinese lung cancer patients with germline mutations

Author

Listed:
  • Wenying Peng

    (Central South University
    Yunnan Cancer Hospital & The Third Affiliated Hospital of Kunming Medical University & Yunnan Cancer Center)

  • Bin Li

    (Central South University
    Central South University)

  • Jin Li

    (Geneplus-Beijing)

  • Lianpeng Chang

    (Geneplus-Beijing)

  • Jing Bai

    (Geneplus-Beijing)

  • Yuting Yi

    (Geneplus-Beijing)

  • Rongrong Chen

    (Geneplus-Beijing)

  • Yanyan Zhang

    (Geneplus-Beijing)

  • Chen Chen

    (Geneplus-Beijing)

  • Xingxiang Pu

    (Central South University)

  • Meilin Jiang

    (Central South University)

  • Jia Li

    (Central South University)

  • Rui Zhong

    (Central South University)

  • Fang Xu

    (Central South University)

  • Bolin Chen

    (Central South University)

  • Li Xu

    (Central South University)

  • Ning Wang

    (The PLA Rocket Force Characteristic Medical Center)

  • Jiaojiao Huan

    (Geneplus-Beijing)

  • Pingping Dai

    (Geneplus-Beijing)

  • Yanfang Guan

    (Geneplus-Beijing)

  • Ling Yang

    (Geneplus-Beijing)

  • Xuefeng Xia

    (Geneplus-Beijing)

  • Xin Yi

    (Geneplus-Beijing)

  • Jiayin Wang

    (Xi’an Jiaotong University)

  • Fenglei Yu

    (The Second Xiangya Hospital of Central South University)

  • Lin Wu

    (Central South University)

Abstract

The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 cancer genes of 1,794 Chinese lung cancer patients was analyzed. A total of 111 pathogenic or likely pathogenic germline mutations were identified, significantly higher than non-cancer individuals (111/1794 vs. 84/10,588, p

Suggested Citation

  • Wenying Peng & Bin Li & Jin Li & Lianpeng Chang & Jing Bai & Yuting Yi & Rongrong Chen & Yanyan Zhang & Chen Chen & Xingxiang Pu & Meilin Jiang & Jia Li & Rui Zhong & Fang Xu & Bolin Chen & Li Xu & Ni, 2022. "Clinical and genomic features of Chinese lung cancer patients with germline mutations," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28840-5
    DOI: 10.1038/s41467-022-28840-5
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    References listed on IDEAS

    as
    1. Nick Patterson & Alkes L Price & David Reich, 2006. "Population Structure and Eigenanalysis," PLOS Genetics, Public Library of Science, vol. 2(12), pages 1-20, December.
    2. Xin Hu & Junya Fujimoto & Lisha Ying & Junya Fukuoka & Kazuto Ashizawa & Wenyong Sun & Alexandre Reuben & Chi-Wan Chow & Nicholas McGranahan & Runzhe Chen & Jinlin Hu & Myrna C. Godoy & Kazuhiro Tabat, 2019. "Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    3. Charles Lu & Mingchao Xie & Michael C. Wendl & Jiayin Wang & Michael D. McLellan & Mark D. M. Leiserson & Kuan-lin Huang & Matthew A. Wyczalkowski & Reyka Jayasinghe & Tapahsama Banerjee & Jie Ning & , 2015. "Patterns and functional implications of rare germline variants across 12 cancer types," Nature Communications, Nature, vol. 6(1), pages 1-13, December.
    4. Ludmil B. Alexandrov & Serena Nik-Zainal & David C. Wedge & Samuel A. J. R. Aparicio & Sam Behjati & Andrew V. Biankin & Graham R. Bignell & Niccolò Bolli & Ake Borg & Anne-Lise Børresen-Dale & Sandri, 2013. "Correction: Corrigendum: Signatures of mutational processes in human cancer," Nature, Nature, vol. 502(7470), pages 258-258, October.
    5. Ludmil B. Alexandrov & Serena Nik-Zainal & David C. Wedge & Samuel A. J. R. Aparicio & Sam Behjati & Andrew V. Biankin & Graham R. Bignell & Niccolò Bolli & Ake Borg & Anne-Lise Børresen-Dale & Sandri, 2013. "Signatures of mutational processes in human cancer," Nature, Nature, vol. 500(7463), pages 415-421, August.
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