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MYC reshapes CTCF-mediated chromatin architecture in prostate cancer

Author

Listed:
  • Zhao Wei

    (Qilu Hospital of Shandong University)

  • Song Wang

    (Shandong University
    Shandong Engineering & Technology Research Center for Tumor Marker Detection
    Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory)

  • Yaning Xu

    (Shandong University
    Shandong Engineering & Technology Research Center for Tumor Marker Detection
    Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory)

  • Wenzheng Wang

    (Shandong University
    Shandong Engineering & Technology Research Center for Tumor Marker Detection
    Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory)

  • Fraser Soares

    (Princess Margaret Cancer Center/University Health Network)

  • Musaddeque Ahmed

    (Princess Margaret Cancer Center/University Health Network)

  • Ping Su

    (National Administration of Health Data)

  • Tingting Wang

    (Shandong University)

  • Elias Orouji

    (Epigenetics Initiative, Princess Margaret Genomics Centre
    University of Texas MD Anderson Cancer Center)

  • Xin Xu

    (Princess Margaret Cancer Center/University Health Network)

  • Yong Zeng

    (Princess Margaret Cancer Center/University Health Network)

  • Sujun Chen

    (Princess Margaret Cancer Center/University Health Network)

  • Xiaoyu Liu

    (Shandong University
    Shandong Engineering & Technology Research Center for Tumor Marker Detection
    Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory)

  • Tianwei Jia

    (Shandong University
    Shandong Engineering & Technology Research Center for Tumor Marker Detection
    Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory)

  • Zhaojian Liu

    (Shandong University)

  • Lutao Du

    (Shandong University
    Shandong Engineering & Technology Research Center for Tumor Marker Detection
    Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory)

  • Yunshan Wang

    (Shandong University
    Shandong Engineering & Technology Research Center for Tumor Marker Detection
    Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory)

  • Shaoyong Chen

    (Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Chuanxin Wang

    (Shandong University
    Shandong Engineering & Technology Research Center for Tumor Marker Detection
    Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory)

  • Housheng Hansen He

    (Princess Margaret Cancer Center/University Health Network
    University of Toronto)

  • Haiyang Guo

    (Shandong University
    Shandong Engineering & Technology Research Center for Tumor Marker Detection
    Shandong Provincial Clinical Medicine Research Center for Clinical Laboratory)

Abstract

MYC is a well characterized oncogenic transcription factor in prostate cancer, and CTCF is the main architectural protein of three-dimensional genome organization. However, the functional link between the two master regulators has not been reported. In this study, we find that MYC rewires prostate cancer chromatin architecture by interacting with CTCF protein. Through combining the H3K27ac, AR and CTCF HiChIP profiles with CRISPR deletion of a CTCF site upstream of MYC gene, we show that MYC activation leads to profound changes of CTCF-mediated chromatin looping. Mechanistically, MYC colocalizes with CTCF at a subset of genomic sites, and enhances CTCF occupancy at these loci. Consequently, the CTCF-mediated chromatin looping is potentiated by MYC activation, resulting in the disruption of enhancer-promoter looping at neuroendocrine lineage plasticity genes. Collectively, our findings define the function of MYC as a CTCF co-factor in three-dimensional genome organization.

Suggested Citation

  • Zhao Wei & Song Wang & Yaning Xu & Wenzheng Wang & Fraser Soares & Musaddeque Ahmed & Ping Su & Tingting Wang & Elias Orouji & Xin Xu & Yong Zeng & Sujun Chen & Xiaoyu Liu & Tianwei Jia & Zhaojian Liu, 2023. "MYC reshapes CTCF-mediated chromatin architecture in prostate cancer," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37544-3
    DOI: 10.1038/s41467-023-37544-3
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    References listed on IDEAS

    as
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