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Epigenetic mechanisms underlying subtype heterogeneity and tumor recurrence in prostate cancer

Author

Listed:
  • Goutam Chakraborty

    (Departments of Urology
    Oncological Sciences)

  • Kasmira Gupta

    (Departments of Urology)

  • Natasha Kyprianou

    (Departments of Urology
    Oncological Sciences
    Pathology & Cell Based Medicine
    Tisch Cancer Institute; Icahn School of Medicine at Mount Sinai)

Abstract

Prostate cancer is a highly heterogeneous disease. Progression on androgen deprivation therapy (ADT) to castration-resistant (CRPC), or neuroendocrine prostate cancer (NEPC), is associated with poor patient survival. This comment highlights recent evidence on the epigenetic mechanisms underlying the emergence of lineage plasticity and neuroendocrine differentiation in treatment-resistant prostate tumors.

Suggested Citation

  • Goutam Chakraborty & Kasmira Gupta & Natasha Kyprianou, 2023. "Epigenetic mechanisms underlying subtype heterogeneity and tumor recurrence in prostate cancer," Nature Communications, Nature, vol. 14(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36253-1
    DOI: 10.1038/s41467-023-36253-1
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