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Epigenetic mechanisms underlying subtype heterogeneity and tumor recurrence in prostate cancer

Author

Listed:
  • Goutam Chakraborty

    (Departments of Urology
    Oncological Sciences)

  • Kasmira Gupta

    (Departments of Urology)

  • Natasha Kyprianou

    (Departments of Urology
    Oncological Sciences
    Pathology & Cell Based Medicine
    Tisch Cancer Institute; Icahn School of Medicine at Mount Sinai)

Abstract

Prostate cancer is a highly heterogeneous disease. Progression on androgen deprivation therapy (ADT) to castration-resistant (CRPC), or neuroendocrine prostate cancer (NEPC), is associated with poor patient survival. This comment highlights recent evidence on the epigenetic mechanisms underlying the emergence of lineage plasticity and neuroendocrine differentiation in treatment-resistant prostate tumors.

Suggested Citation

  • Goutam Chakraborty & Kasmira Gupta & Natasha Kyprianou, 2023. "Epigenetic mechanisms underlying subtype heterogeneity and tumor recurrence in prostate cancer," Nature Communications, Nature, vol. 14(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36253-1
    DOI: 10.1038/s41467-023-36253-1
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    References listed on IDEAS

    as
    1. Sebnem Ece Eksi & Alex Chitsazan & Zeynep Sayar & George V. Thomas & Andrew J. Fields & Ryan P. Kopp & Paul T. Spellman & Andrew C. Adey, 2021. "Epigenetic loss of heterogeneity from low to high grade localized prostate tumours," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Haiyang Guo & Xinpei Ci & Musaddeque Ahmed & Junjie Tony Hua & Fraser Soares & Dong Lin & Loredana Puca & Aram Vosoughi & Hui Xue & Estelle Li & Peiran Su & Sujun Chen & Tran Nguyen & Yi Liang & Yuzhe, 2019. "ONECUT2 is a driver of neuroendocrine prostate cancer," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    3. Shaghayegh Nouruzi & Dwaipayan Ganguli & Nakisa Tabrizian & Maxim Kobelev & Olena Sivak & Takeshi Namekawa & Daksh Thaper & Sylvan C. Baca & Matthew L. Freedman & Adeleke Aguda & Alastair Davies & Ami, 2022. "ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancer," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
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