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Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

Author

Listed:
  • Irfan A. Asangani

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Vijaya L. Dommeti

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Xiaoju Wang

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Rohit Malik

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Marcin Cieslik

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Rendong Yang

    (Emory University)

  • June Escara-Wilke

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Kari Wilder-Romans

    (University of Michigan Medical School)

  • Sudheer Dhanireddy

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Carl Engelke

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Mathew K. Iyer

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Xiaojun Jing

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Yi-Mi Wu

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Xuhong Cao

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    Howard Hughes Medical Institute, University of Michigan Medical School)

  • Zhaohui S. Qin

    (Emory University)

  • Shaomeng Wang

    (Pharmacology, and Medicinal Chemistry, University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School)

  • Felix Y. Feng

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School)

  • Arul M. Chinnaiyan

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School
    Howard Hughes Medical Institute, University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School)

Abstract

Small-molecule compounds that target the BET domain in proteins such as BRD4 have recently been identified as potential anticancer agents; here, the efficacy of the BRD4-targeting compound JQ1 is demonstrated in castration-resistant prostate cancer driven by deregulated androgen receptor action.

Suggested Citation

  • Irfan A. Asangani & Vijaya L. Dommeti & Xiaoju Wang & Rohit Malik & Marcin Cieslik & Rendong Yang & June Escara-Wilke & Kari Wilder-Romans & Sudheer Dhanireddy & Carl Engelke & Mathew K. Iyer & Xiaoju, 2014. "Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer," Nature, Nature, vol. 510(7504), pages 278-282, June.
    • Handle: RePEc:nat:nature:v:510:y:2014:i:7504:d:10.1038_nature13229
    DOI: 10.1038/nature13229
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    Citations

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    Cited by:

    1. Zhao Wei & Song Wang & Yaning Xu & Wenzheng Wang & Fraser Soares & Musaddeque Ahmed & Ping Su & Tingting Wang & Elias Orouji & Xin Xu & Yong Zeng & Sujun Chen & Xiaoyu Liu & Tianwei Jia & Zhaojian Liu, 2023. "MYC reshapes CTCF-mediated chromatin architecture in prostate cancer," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Reyaz ur Rasool & Caitlin M. O’Connor & Chandan Kanta Das & Mohammed Alhusayan & Brijesh Kumar Verma & Sehbanul Islam & Ingrid E. Frohner & Qu Deng & Erick Mitchell-Velasquez & Jaya Sangodkar & Aqila , 2023. "Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance," Nature Communications, Nature, vol. 14(1), pages 1-24, December.
    3. Donglin Ding & Rongbin Zheng & Ye Tian & Rafael Jimenez & Xiaonan Hou & Saravut J. Weroha & Liguo Wang & Lei Shi & Haojie Huang, 2022. "Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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