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High-resolution separation of bioisomers using ion cloud profiling

Author

Listed:
  • Xiaoyu Zhou

    (Tsinghua University
    Tsinghua University)

  • Zhuofan Wang

    (Tsinghua University)

  • Jingjin Fan

    (Tsinghua University)

  • Zheng Ouyang

    (Tsinghua University
    Tsinghua University)

Abstract

Elucidation of complex structures of biomolecules plays a key role in the field of chemistry and life sciences. In the past decade, ion mobility, by coupling with mass spectrometry, has become a unique tool for distinguishing isomers and isoforms of biomolecules. In this study, we develop a concept for performing ion mobility analysis using an ion trap, which enables isomer separation under ultra-high fields to achieve super high resolutions over 10,000. The potential of this technology has been demonstrated for analysis of isomers for biomolecules including disaccharides, phospholipids, and peptides with post-translational modifications.

Suggested Citation

  • Xiaoyu Zhou & Zhuofan Wang & Jingjin Fan & Zheng Ouyang, 2023. "High-resolution separation of bioisomers using ion cloud profiling," Nature Communications, Nature, vol. 14(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37281-7
    DOI: 10.1038/s41467-023-37281-7
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    References listed on IDEAS

    as
    1. J. Hofmann & H. S. Hahm & P. H. Seeberger & K. Pagel, 2015. "Identification of carbohydrate anomers using ion mobility–mass spectrometry," Nature, Nature, vol. 526(7572), pages 241-244, October.
    2. Arthur Laganowsky & Eamonn Reading & Timothy M. Allison & Martin B. Ulmschneider & Matteo T. Degiacomi & Andrew J. Baldwin & Carol V. Robinson, 2014. "Membrane proteins bind lipids selectively to modulate their structure and function," Nature, Nature, vol. 510(7503), pages 172-175, June.
    3. Wenbo Cao & Simin Cheng & Jing Yang & Jiaxin Feng & Wenpeng Zhang & Zishuai Li & Qinhua Chen & Yu Xia & Zheng Ouyang & Xiaoxiao Ma, 2020. "Large-scale lipid analysis with C=C location and sn-position isomer resolving power," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
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