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Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery

Author

Listed:
  • Ivan V. Zelepukin

    (Uppsala University
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences)

  • Konstantin G. Shevchenko

    (Boston University)

  • Sergey M. Deyev

    (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences)

Abstract

Rapid uptake of nanoparticles by mononuclear phagocyte system (MPS) significantly hampers their therapeutic efficacy. Temporal MPS blockade is one of the few ways to overcome this barrier – the approach rediscovered many times under different names but never extensively used in clinic. Using meta-analysis of the published data we prove the efficacy of this technique for enhancing particle circulation in blood and their delivery to tumours, describe a century of its evolution and potential combined mechanism behind it. Finally, we discuss future directions of the research focusing on the features essential for successful clinical translation of the method.

Suggested Citation

  • Ivan V. Zelepukin & Konstantin G. Shevchenko & Sergey M. Deyev, 2024. "Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48838-5
    DOI: 10.1038/s41467-024-48838-5
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    as
    1. Ivan V. Zelepukin & Olga Yu. Griaznova & Konstantin G. Shevchenko & Andrey V. Ivanov & Ekaterina V. Baidyuk & Natalia B. Serejnikova & Artur B. Volovetskiy & Sergey M. Deyev & Andrei V. Zvyagin, 2022. "Flash drug release from nanoparticles accumulated in the targeted blood vessels facilitates the tumour treatment," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Zheng Li & Yabo Zhu & Haowen Zeng & Chong Wang & Chen Xu & Qiang Wang & Huimin Wang & Shiyou Li & Jitang Chen & Chen Xiao & Xiangliang Yang & Zifu Li, 2023. "Mechano-boosting nanomedicine antitumour efficacy by blocking the reticuloendothelial system with stiff nanogels," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
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