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Large-scale genomic analyses reveal alterations and mechanisms underlying clonal evolution and immune evasion in esophageal cancer

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  • De-Chen Lin

    (University of Southern California
    University of Southern California)

Abstract

Esophageal cancers feature distinct manifestations between and within patients which complicate precision diagnosis, prognosis, and patient care. New genomic and epigenomic research uncovers novel mechanisms underlying both inter- and intra-tumoral heterogeneity in esophageal cancer, with significant biological and translational implications.

Suggested Citation

  • De-Chen Lin, 2023. "Large-scale genomic analyses reveal alterations and mechanisms underlying clonal evolution and immune evasion in esophageal cancer," Nature Communications, Nature, vol. 14(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36557-2
    DOI: 10.1038/s41467-023-36557-2
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    References listed on IDEAS

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    1. Yingxia Zheng & Zheyi Chen & Yichao Han & Li Han & Xin Zou & Bingqian Zhou & Rui Hu & Jie Hao & Shihao Bai & Haibo Xiao & Wei Vivian Li & Alex Bueker & Yanhui Ma & Guohua Xie & Junyao Yang & Shiyu Che, 2020. "Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    2. Minghao Li & Zicheng Zhang & Qianrong Wang & Yan Yi & Baosheng Li, 2022. "Integrated cohort of esophageal squamous cell cancer reveals genomic features underlying clinical characteristics," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Huy Q. Dinh & Feng Pan & Geng Wang & Qing-Feng Huang & Claire E. Olingy & Zhi-Yong Wu & Shao-Hong Wang & Xin Xu & Xiu-E Xu & Jian-Zhong He & Qian Yang & Sandra Orsulic & Marcela Haro & Li-Yan Li & Guo, 2021. "Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    4. Xiannian Zhang & Linna Peng & Yingying Luo & Shaosen Zhang & Yang Pu & Yamei Chen & Wenjia Guo & Jiacheng Yao & Mingming Shao & Wenyi Fan & Qionghua Cui & Yiyi Xi & Yanxia Sun & Xiangjie Niu & Xuan Zh, 2021. "Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    5. Ting Yan & Heyang Cui & Yong Zhou & Bin Yang & Pengzhou Kong & Yingchun Zhang & Yiqian Liu & Bin Wang & Yikun Cheng & Jiayi Li & Shixing Guo & Enwei Xu & Huijuan Liu & Caixia Cheng & Ling Zhang & Ling, 2019. "Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    6. Akira Yokoyama & Nobuyuki Kakiuchi & Tetsuichi Yoshizato & Yasuhito Nannya & Hiromichi Suzuki & Yasuhide Takeuchi & Yusuke Shiozawa & Yusuke Sato & Kosuke Aoki & Soo Ki Kim & Yoichi Fujii & Kenichi Yo, 2019. "Age-related remodelling of oesophageal epithelia by mutated cancer drivers," Nature, Nature, vol. 565(7739), pages 312-317, January.
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    Cited by:

    1. Yan Zhao & Changchun Ma & Rongzhi Cai & Lijing Xin & Yongsheng Li & Lixin Ke & Wei Ye & Ting Ouyang & Jiahao Liang & Renhua Wu & Yan Lin, 2024. "NMR and MS reveal characteristic metabolome atlas and optimize esophageal squamous cell carcinoma early detection," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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