IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-36519-8.html
   My bibliography  Save this article

Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice

Author

Listed:
  • Hanseul Park

    (Dongguk University)

  • Byounggook Cho

    (Dongguk University)

  • Hongwon Kim

    (Dongguk University)

  • Takashi Saito

    (RIKEN Center for Brain Science
    Nagoya City University Graduate School of Medical Sciences)

  • Takaomi C. Saido

    (RIKEN Center for Brain Science)

  • Kyoung-Jae Won

    (Cedars-Sinai Medical Center 700 N)

  • Jongpil Kim

    (Dongguk University)

Abstract

Alzheimer’s disease (AD) is associated with progressive neuronal degeneration as amyloid-beta (Aβ) and tau proteins accumulate in the brain. Glial cells were recently reported to play an important role in the development of AD. However, little is known about the role of oligodendrocytes in AD pathogenesis. Here, we describe a disease-associated subpopulation of oligodendrocytes that is present during progression of AD-like pathology in the male AppNL-G-F and male 5xFAD AD mouse brains and in postmortem AD human brains using single-cell RNA sequencing analysis. Aberrant Erk1/2 signaling was found to be associated with the activation of disease-associated oligodendrocytes (DAOs) in male AppNL-G-F mouse brains. Notably, inhibition of Erk1/2 signaling in DAOs rescued impaired axonal myelination and ameliorated Aβ-associated pathologies and cognitive decline in the male AppNL-G-F AD mouse model.

Suggested Citation

  • Hanseul Park & Byounggook Cho & Hongwon Kim & Takashi Saito & Takaomi C. Saido & Kyoung-Jae Won & Jongpil Kim, 2023. "Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36519-8
    DOI: 10.1038/s41467-023-36519-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-36519-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-36519-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Tao Lu & Liviu Aron & Joseph Zullo & Ying Pan & Haeyoung Kim & Yiwen Chen & Tun-Hsiang Yang & Hyun-Min Kim & Derek Drake & X. Shirley Liu & David A. Bennett & Monica P. Colaiácovo & Bruce A. Yankner, 2014. "REST and stress resistance in ageing and Alzheimer’s disease," Nature, Nature, vol. 507(7493), pages 448-454, March.
    2. Ursula Fünfschilling & Lotti M. Supplie & Don Mahad & Susann Boretius & Aiman S. Saab & Julia Edgar & Bastian G. Brinkmann & Celia M. Kassmann & Iva D. Tzvetanova & Wiebke Möbius & Francisca Diaz & Di, 2012. "Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity," Nature, Nature, vol. 485(7399), pages 517-521, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kunkun Zhang & Shaoxuan Chen & Qihua Yang & Shuanghui Guo & Qiang Chen & Zhixiong Liu & Li Li & Mengyun Jiang & Hongda Li & Jin Hu & Xu Pan & Wenbo Deng & Naian Xiao & Bo Wang & Zhan-xiang Wang & Lian, 2022. "The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Xiao-Ru Ma & Xudong Zhu & Yujie Xiao & Hui-Min Gu & Shuang-Shuang Zheng & Liang Li & Fan Wang & Zhao-Jun Dong & Di-Xian Wang & Yang Wu & Chenyu Yang & Wenhong Jiang & Ke Yao & Yue Yin & Yang Zhang & C, 2022. "Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Siyi He & Yue Zhao & Yongsheng Fan & Xue Zhao & Jun Yu & Jie Xie & Chunhong Wang & Jianmei Su, 2019. "Research Trends and Hotspots Analysis Related to Monocarboxylate Transporter 1: A Study Based on Bibliometric Analysis," IJERPH, MDPI, vol. 16(7), pages 1-15, March.
    4. Kielen R. Zuurbier & Rene Solano Fonseca & Sonja L. B. Arneaud & Jordan M. Wall & Juhee Kim & Lexus Tatge & Gupse Otuzoglu & Sofia Bali & Patrick Metang & Peter M. Douglas, 2024. "Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    5. Xhoela Bame & Robert A. Hill, 2024. "Mitochondrial network reorganization and transient expansion during oligodendrocyte generation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    6. Wenwu Zeng & Yutao Dou & Liangrui Pan & Liwen Xu & Shaoliang Peng, 2024. "Improving prediction performance of general protein language model by domain-adaptive pretraining on DNA-binding protein," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    7. Liviu Aron & Chenxi Qiu & Zhen Kai Ngian & Marianna Liang & Derek Drake & Jaejoon Choi & Marty A. Fernandez & Perle Roche & Emma L. Bunting & Ella K. Lacey & Sara E. Hamplova & Monlan Yuan & Michael S, 2023. "A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer’s disease," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36519-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.