IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v485y2012i7399d10.1038_nature11007.html
   My bibliography  Save this article

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

Author

Listed:
  • Ursula Fünfschilling

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Lotti M. Supplie

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Don Mahad

    (Mitochondrial Research Group, Institute for Ageing and Health, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Present addresses: Center for Neuroregeneration, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK (D.M.); Department of Molecular Physiology, Institute of Physiology, University of Saarland, D-66421 Homburg, Germany (A.S.S.); Department of Neurosurgery, Charité-University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany (B.G.B.); Department of Diagnostic Radiology, Am Botanischen Garten 14, University of Kiel, D-24118 Kiel, Germany.)

  • Susann Boretius

    (Biomedizinische NMR Forschungs GmbH am Max Planck Institute of Biophysical Chemistry, D-37070 Göttingen, Germany)

  • Aiman S. Saab

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
    Present addresses: Center for Neuroregeneration, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK (D.M.); Department of Molecular Physiology, Institute of Physiology, University of Saarland, D-66421 Homburg, Germany (A.S.S.); Department of Neurosurgery, Charité-University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany (B.G.B.); Department of Diagnostic Radiology, Am Botanischen Garten 14, University of Kiel, D-24118 Kiel, Germany.)

  • Julia Edgar

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Bastian G. Brinkmann

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
    Present addresses: Center for Neuroregeneration, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK (D.M.); Department of Molecular Physiology, Institute of Physiology, University of Saarland, D-66421 Homburg, Germany (A.S.S.); Department of Neurosurgery, Charité-University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany (B.G.B.); Department of Diagnostic Radiology, Am Botanischen Garten 14, University of Kiel, D-24118 Kiel, Germany.)

  • Celia M. Kassmann

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Iva D. Tzvetanova

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Wiebke Möbius

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
    Present addresses: Center for Neuroregeneration, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK (D.M.); Department of Molecular Physiology, Institute of Physiology, University of Saarland, D-66421 Homburg, Germany (A.S.S.); Department of Neurosurgery, Charité-University Medicine Berlin, Charitéplatz 1, D-10117 Berlin, Germany (B.G.B.); Department of Diagnostic Radiology, Am Botanischen Garten 14, University of Kiel, D-24118 Kiel, Germany.)

  • Francisca Diaz

    (University of Miami, Miller School of Medicine, 1095 NW 14th Terrace, Miami, Florida 33136, USA)

  • Dies Meijer

    (Erasmus MC, 3000 CA Rotterdam, Netherlands)

  • Ueli Suter

    (Institute of Cell Biology, ETH Hönggerberg, Schafmattstrasse 18, 8093 Zürich, Switzerland)

  • Bernd Hamprecht

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Michael W. Sereda

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany
    University of Göttingen (UMG), Robert-Koch-Strasse 40, D-37075 Göttingen, Germany)

  • Carlos T. Moraes

    (University of Miami, Miller School of Medicine, 1095 NW 14th Terrace, Miami, Florida 33136, USA)

  • Jens Frahm

    (Biomedizinische NMR Forschungs GmbH am Max Planck Institute of Biophysical Chemistry, D-37070 Göttingen, Germany)

  • Sandra Goebbels

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

  • Klaus-Armin Nave

    (Max Planck Institute of Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Göttingen, Germany)

Abstract

After myelination, oligodendrocytes are able to survive without mitochondrial respiration, suggesting that they can switch to aerobic glycolysis and release lactate.

Suggested Citation

  • Ursula Fünfschilling & Lotti M. Supplie & Don Mahad & Susann Boretius & Aiman S. Saab & Julia Edgar & Bastian G. Brinkmann & Celia M. Kassmann & Iva D. Tzvetanova & Wiebke Möbius & Francisca Diaz & Di, 2012. "Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity," Nature, Nature, vol. 485(7399), pages 517-521, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7399:d:10.1038_nature11007
    DOI: 10.1038/nature11007
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11007
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11007?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kunkun Zhang & Shaoxuan Chen & Qihua Yang & Shuanghui Guo & Qiang Chen & Zhixiong Liu & Li Li & Mengyun Jiang & Hongda Li & Jin Hu & Xu Pan & Wenbo Deng & Naian Xiao & Bo Wang & Zhan-xiang Wang & Lian, 2022. "The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Xiao-Ru Ma & Xudong Zhu & Yujie Xiao & Hui-Min Gu & Shuang-Shuang Zheng & Liang Li & Fan Wang & Zhao-Jun Dong & Di-Xian Wang & Yang Wu & Chenyu Yang & Wenhong Jiang & Ke Yao & Yue Yin & Yang Zhang & C, 2022. "Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Xhoela Bame & Robert A. Hill, 2024. "Mitochondrial network reorganization and transient expansion during oligodendrocyte generation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    4. Siyi He & Yue Zhao & Yongsheng Fan & Xue Zhao & Jun Yu & Jie Xie & Chunhong Wang & Jianmei Su, 2019. "Research Trends and Hotspots Analysis Related to Monocarboxylate Transporter 1: A Study Based on Bibliometric Analysis," IJERPH, MDPI, vol. 16(7), pages 1-15, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:485:y:2012:i:7399:d:10.1038_nature11007. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.