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Durability and cross-reactivity of immune responses induced by a plant-based virus-like particle vaccine for COVID-19

Author

Listed:
  • Philipe Gobeil

    (Medicago Inc.)

  • Stéphane Pillet

    (Medicago Inc.)

  • Iohann Boulay

    (Medicago Inc.)

  • Nathalie Charland

    (Medicago Inc.)

  • Aurélien Lorin

    (Medicago Inc.)

  • Matthew P. Cheng

    (The Research Institute of the McGill University Health Centre)

  • Donald C. Vinh

    (The Research Institute of the McGill University Health Centre)

  • Philippe Boutet

    (GlaxoSmithKline (Vaccines))

  • Robbert Most

    (GlaxoSmithKline (Vaccines)
    BioNTech)

  • François Roman

    (GlaxoSmithKline (Vaccines))

  • Maria Angeles Ceregido

    (GlaxoSmithKline (Vaccines))

  • Nathalie Landry

    (Medicago Inc.)

  • Marc-André D’Aoust

    (Medicago Inc.)

  • Brian J. Ward

    (Medicago Inc.
    The Research Institute of the McGill University Health Centre)

Abstract

As the SARS-CoV-2 pandemic evolves, vaccine evaluation needs to include consideration of both durability and cross-reactivity. This report expands on previously reported results from a Phase 1 trial of an AS03-adjuvanted, plant-based coronavirus-like particle (CoVLP) displaying the spike (S) glycoprotein of the ancestral SARS-CoV-2 virus in healthy adults (NCT04450004). Humoral and cellular responses against the ancestral strain were evaluated 6 months post-second dose (D201) as secondary outcomes. Independent of dose, all vaccinated individuals retain binding antibodies, and ~95% retain neutralizing antibodies (NAb). Interferon gamma and interleukin-4 responses remain detectable in ~94% and ~92% of vaccinees respectively. In post-hoc analyses, variant-specific (Alpha, Beta, Delta, Gamma and Omicron) NAb were assessed at D42 and D201. Using a live virus neutralization assay, broad cross-reactivity is detectable against all variants at D42. At D201, cross-reactive antibodies are detectable in almost all participants against Alpha, Gamma and Delta variants (94%) and the Beta variant (83%) and in a smaller proportion against Omicron (44%). Results are similar with the pseudovirion assay. These data suggest that two doses of 3.75 µg CoVLP+AS03 elicit a durable and cross-reactive response that persists for at least 6 months post-vaccination.

Suggested Citation

  • Philipe Gobeil & Stéphane Pillet & Iohann Boulay & Nathalie Charland & Aurélien Lorin & Matthew P. Cheng & Donald C. Vinh & Philippe Boutet & Robbert Most & François Roman & Maria Angeles Ceregido & N, 2022. "Durability and cross-reactivity of immune responses induced by a plant-based virus-like particle vaccine for COVID-19," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34728-1
    DOI: 10.1038/s41467-022-34728-1
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