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Molecularly self‐fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke

Author

Listed:
  • Hongyuan Zhang

    (Shenyang Pharmaceutical University)

  • Zhiqiang Zhao

    (Shenyang Pharmaceutical University)

  • Shengnan Sun

    (Shenyang Pharmaceutical University)

  • Sen Zhang

    (Shenyang Pharmaceutical University)

  • Yuequan Wang

    (Shenyang Pharmaceutical University)

  • Xuanbo Zhang

    (Shenyang Pharmaceutical University)

  • Jin Sun

    (Shenyang Pharmaceutical University)

  • Zhonggui He

    (Shenyang Pharmaceutical University)

  • Shenwu Zhang

    (Shenyang Pharmaceutical University)

  • Cong Luo

    (Shenyang Pharmaceutical University)

Abstract

Thrombotic cerebro-cardiovascular diseases are the leading causes of disability and death worldwide. However, current drug therapeutics are compromised by narrow therapeutic windows, unsatisfactory thrombolysis effects, severe bleeding events, and high recurrence rates. In this study, we exploit a self-propelling nano-penetrator with high fuel loading and controllable motion features, which is molecularly co-assembled using a photothermal photosensitizer (DiR) and a photothermal-activable NO donor (BNN6). The precisely engineered nano-penetrator of the BNN6-DiR fuel pair shows distinct advantages in terms of NO productivity and autonomous motion under laser irradiation. In animal models of artery/vein thrombosis and acute ischemic stroke, the self‐fueled nano-penetrator enables self-navigated thrombus-homing accumulation, self-propelled clot deep penetration, fluorescence image-guided photothermal/mechanical thrombolysis, and NO-mediated prevention of thrombosis recurrence and acute ischemic stroke salvage. As expected, the molecularly self-fueled nano-penetrator displayed favorable therapeutic outcomes without bleeding risk compared to the clinically available thrombolytic drug. This study offers a facile, safe, and effective nonpharmaceutical modality towards the clinical treatment of thrombosis and ischemic stroke.

Suggested Citation

  • Hongyuan Zhang & Zhiqiang Zhao & Shengnan Sun & Sen Zhang & Yuequan Wang & Xuanbo Zhang & Jin Sun & Zhonggui He & Shenwu Zhang & Cong Luo, 2023. "Molecularly self‐fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35895-5
    DOI: 10.1038/s41467-023-35895-5
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    References listed on IDEAS

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    1. Nigel Mackman, 2008. "Triggers, targets and treatments for thrombosis," Nature, Nature, vol. 451(7181), pages 914-918, February.
    2. Mimi Wan & Huan Chen & Qi Wang & Qian Niu & Ping Xu & Yueqi Yu & Tianyu Zhu & Chun Mao & Jian Shen, 2019. "Bio-inspired nitric-oxide-driven nanomotor," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
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    Cited by:

    1. Weiyue Ban & Mengchi Sun & Hanwei Huang & Wanxu Huang & Siwei Pan & Pengfei Liu & Bingwu Li & Zhenguo Cheng & Zhonggui He & Funan Liu & Jin Sun, 2023. "Engineered bacterial outer membrane vesicles encapsulating oncolytic adenoviruses enhance the efficacy of cancer virotherapy by augmenting tumor cell autophagy," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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