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Bio-inspired nitric-oxide-driven nanomotor

Author

Listed:
  • Mimi Wan

    (Nanjing Normal University)

  • Huan Chen

    (Nanjing Normal University)

  • Qi Wang

    (Nanjing Normal University)

  • Qian Niu

    (Nanjing Normal University)

  • Ping Xu

    (Nanjing Normal University)

  • Yueqi Yu

    (Nanjing Normal University)

  • Tianyu Zhu

    (Nanjing Normal University)

  • Chun Mao

    (Nanjing Normal University)

  • Jian Shen

    (Nanjing Normal University)

Abstract

Current chemical-fuel-driven nanomotors are driven by gas (e.g. H2, O2, NH3) which only provides motion ability, and can produce waste (e.g. Mg(OH)2, Pt). Here, inspired by endogenous biochemical reactions in the human body involving conversion of amino acid L-arginine to nitric oxide (NO) by NO synthase (NOS) or reactive oxygen species (ROS), we report on a nanomotor made of hyperbranched polyamide/L-arginine (HLA). The nanomotor utilizes L-arginine as fuel for the production of NO both as driving force and to provide beneficial effects, including promoting endothelialisation and anticancer effects, along with other beneficial by-products. In addition, the HLA nanomotors are fluorescent and can be used to monitor the movement of nanomotors in vivo in the future. This work presents a zero-waste, self-destroyed and self-imaging nanomotor with potential biological application for the treatment of various diseases in different tissues including blood vessels and tumours.

Suggested Citation

  • Mimi Wan & Huan Chen & Qi Wang & Qian Niu & Ping Xu & Yueqi Yu & Tianyu Zhu & Chun Mao & Jian Shen, 2019. "Bio-inspired nitric-oxide-driven nanomotor," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08670-8
    DOI: 10.1038/s41467-019-08670-8
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    Cited by:

    1. Hongyuan Zhang & Zhiqiang Zhao & Shengnan Sun & Sen Zhang & Yuequan Wang & Xuanbo Zhang & Jin Sun & Zhonggui He & Shenwu Zhang & Cong Luo, 2023. "Molecularly self‐fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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