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Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

Author

Listed:
  • Alexxai V. Kravitz

    (Gladstone Institute of Neurological Disease)

  • Benjamin S. Freeze

    (Gladstone Institute of Neurological Disease
    Biomedical Sciences Program, University of California
    Medical Scientist Training Program, University of California)

  • Philip R. L. Parker

    (Gladstone Institute of Neurological Disease
    Neuroscience Graduate Program, University of California)

  • Kenneth Kay

    (Gladstone Institute of Neurological Disease
    Medical Scientist Training Program, University of California)

  • Myo T. Thwin

    (Gladstone Institute of Neurological Disease)

  • Karl Deisseroth

    (Stanford University)

  • Anatol C. Kreitzer

    (Gladstone Institute of Neurological Disease
    University of California
    Neuroscience Graduate Program, University of California
    Biomedical Sciences Program, University of California)

Abstract

Control of parkinsonian behaviour The basal ganglia are a collection of interconnected brain areas thought to be crucial for motor planning, sequencing and execution. It has long been thought that motor control is achieved through the balanced activity of two parallel and anatomically distinct pathways, acting on the basal ganglia with opposing effects, but these pathways have never been functionally verified. Kravitz et al. have tested this hypothesis directly using optogenetic activation of different populations of mouse striatal neurons, and they both trace functional connectivity and demonstrate opposing effects on motor behaviour. Selective activation of the 'direct' pathway increased locomotion and rescued motor deficits in a parkinsonian model, whereas activation of the 'indirect' pathway suppressed motor behaviour.

Suggested Citation

  • Alexxai V. Kravitz & Benjamin S. Freeze & Philip R. L. Parker & Kenneth Kay & Myo T. Thwin & Karl Deisseroth & Anatol C. Kreitzer, 2010. "Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry," Nature, Nature, vol. 466(7306), pages 622-626, July.
    • Handle: RePEc:nat:nature:v:466:y:2010:i:7306:d:10.1038_nature09159
    DOI: 10.1038/nature09159
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    Cited by:

    1. Marie A. Labouesse & Arturo Torres-Herraez & Muhammad O. Chohan & Joseph M. Villarin & Julia Greenwald & Xiaoxiao Sun & Mysarah Zahran & Alice Tang & Sherry Lam & Jeremy Veenstra-VanderWeele & Clay O., 2023. "A non-canonical striatopallidal Go pathway that supports motor control," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Rosalyn J Moran & Nicolas Mallet & Vladimir Litvak & Raymond J Dolan & Peter J Magill & Karl J Friston & Peter Brown, 2011. "Alterations in Brain Connectivity Underlying Beta Oscillations in Parkinsonism," PLOS Computational Biology, Public Library of Science, vol. 7(8), pages 1-15, August.
    3. Yang, Shuangming & Wei, Xile & Deng, Bin & Liu, Chen & Li, Huiyan & Wang, Jiang, 2018. "Efficient digital implementation of a conductance-based globus pallidus neuron and the dynamics analysis," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 494(C), pages 484-502.
    4. Sorinel A Oprisan & Xandre Clementsmith & Tamas Tompa & Antonieta Lavin, 2019. "Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-39, October.
    5. Miguel Skirzewski & Oren Princz-Lebel & Liliana German-Castelan & Alycia M. Crooks & Gerard Kyungwook Kim & Sophie Henke Tarnow & Amy Reichelt & Sara Memar & Daniel Palmer & Yulong Li & R. Jane Rylett, 2022. "Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    6. Xuandi Hou & Jianing Jing & Yizhou Jiang & Xiaohui Huang & Quanxiang Xian & Ting Lei & Jiejun Zhu & Kin Fung Wong & Xinyi Zhao & Min Su & Danni Li & Langzhou Liu & Zhihai Qiu & Lei Sun, 2024. "Nanobubble-actuated ultrasound neuromodulation for selectively shaping behavior in mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    7. Lizhu Li & Lihui Lu & Yuqi Ren & Guo Tang & Yu Zhao & Xue Cai & Zhao Shi & He Ding & Changbo Liu & Dali Cheng & Yang Xie & Huachun Wang & Xin Fu & Lan Yin & Minmin Luo & Xing Sheng, 2022. "Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    8. Christophe Varin & Amandine Cornil & Delphine Houtteman & Patricia Bonnavion & Alban Kerchove d’Exaerde, 2023. "The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    9. Sean C. Piantadosi & Elizabeth E. Manning & Brittany L. Chamberlain & James Hyde & Zoe LaPalombara & Nicholas M. Bannon & Jamie L. Pierson & Vijay M. K Namboodiri & Susanne E. Ahmari, 2024. "Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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