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Intrinsically determined cell death of developing cortical interneurons

Author

Listed:
  • Derek G. Southwell

    (Neuroscience Graduate Program, University of California
    the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California
    Medical Scientist Training Program, University of California)

  • Mercedes F. Paredes

    (the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California
    University of California)

  • Rui P. Galvao

    (the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California
    Present addresses: Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA (D.G.S.); Department of Molecular Biology, University of Oregon, Eugene, Oregon 97403, USA (R.P.G.); Molecular Neurobiology Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, Departments of Otolaryngology, Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA (R.C.F.); Cambridge Centre for Brain Repair, Department of Clinical Neurosciences and Stem Cell Institute, University of Cambridge, Cambridge CB2 0PY, UK (C.A.-C.).)

  • Daniel L. Jones

    (Neuroscience Graduate Program, University of California
    the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

  • Robert C. Froemke

    (Coleman Memorial Laboratory and W.M. Keck Foundation Center for Integrative Neuroscience, University of California
    Present addresses: Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA (D.G.S.); Department of Molecular Biology, University of Oregon, Eugene, Oregon 97403, USA (R.P.G.); Molecular Neurobiology Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, Departments of Otolaryngology, Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA (R.C.F.); Cambridge Centre for Brain Repair, Department of Clinical Neurosciences and Stem Cell Institute, University of Cambridge, Cambridge CB2 0PY, UK (C.A.-C.).)

  • Joy Y. Sebe

    (the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

  • Clara Alfaro-Cervello

    (Instituto Cavanilles, Universidad de Valencia
    Present addresses: Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA (D.G.S.); Department of Molecular Biology, University of Oregon, Eugene, Oregon 97403, USA (R.P.G.); Molecular Neurobiology Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, Departments of Otolaryngology, Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA (R.C.F.); Cambridge Centre for Brain Repair, Department of Clinical Neurosciences and Stem Cell Institute, University of Cambridge, Cambridge CB2 0PY, UK (C.A.-C.).)

  • Yunshuo Tang

    (the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California
    Medical Scientist Training Program, University of California
    Biomedical Sciences Graduate Program, University of California)

  • Jose M. Garcia-Verdugo

    (Instituto Cavanilles, Universidad de Valencia)

  • John L. Rubenstein

    (University of California)

  • Scott C. Baraban

    (Neuroscience Graduate Program, University of California
    the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

  • Arturo Alvarez-Buylla

    (Neuroscience Graduate Program, University of California
    the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

Abstract

The cell death of inhibitory neurons, which originate far from the cortical areas to which they migrate during embryonic development, is determined autonomously rather than by competition for trophic signals from other cell types.

Suggested Citation

  • Derek G. Southwell & Mercedes F. Paredes & Rui P. Galvao & Daniel L. Jones & Robert C. Froemke & Joy Y. Sebe & Clara Alfaro-Cervello & Yunshuo Tang & Jose M. Garcia-Verdugo & John L. Rubenstein & Scot, 2012. "Intrinsically determined cell death of developing cortical interneurons," Nature, Nature, vol. 491(7422), pages 109-113, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7422:d:10.1038_nature11523
    DOI: 10.1038/nature11523
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    Cited by:

    1. Li-Pao Fang & Na Zhao & Laura C. Caudal & Hsin-Fang Chang & Renping Zhao & Ching-Hsin Lin & Nadine Hainz & Carola Meier & Bernhard Bettler & Wenhui Huang & Anja Scheller & Frank Kirchhoff & Xianshu Ba, 2022. "Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Luke F. Nunnelly & Melissa Campbell & Dylan I. Lee & Patrick Dummer & Guoqiang Gu & Vilas Menon & Edmund Au, 2022. "St18 specifies globus pallidus projection neuron identity in MGE lineage," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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