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Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates

Author

Listed:
  • Moritz Mall

    (Stanford University)

  • Michael S. Kareta

    (Stanford University
    †Present addresses: Genetics and Genomics Group, Sanford Research, Sioux Falls, SD 57104, USA (M.S.K.); Molecular and Cellular Biology, University of California Merced, Merced, CA 95343, USA (X.G.); Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA (T.V.); Leibniz-Institute for Molecular Pharmacology, 13125 Berlin, Germany (P.B.); Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama 230-0045, Japan (K.R.N.).)

  • Soham Chanda

    (Stanford University
    Stanford University)

  • Henrik Ahlenius

    (Lund University)

  • Nicholas Perotti

    (Stanford University)

  • Bo Zhou

    (Stanford University
    Stanford University)

  • Sarah D. Grieder

    (Stanford University)

  • Xuecai Ge

    (Stanford University
    †Present addresses: Genetics and Genomics Group, Sanford Research, Sioux Falls, SD 57104, USA (M.S.K.); Molecular and Cellular Biology, University of California Merced, Merced, CA 95343, USA (X.G.); Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA (T.V.); Leibniz-Institute for Molecular Pharmacology, 13125 Berlin, Germany (P.B.); Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama 230-0045, Japan (K.R.N.).)

  • Sienna Drake

    (Lund University)

  • Cheen Euong Ang

    (Stanford University)

  • Brandon M. Walker

    (Stanford University)

  • Thomas Vierbuchen

    (Stanford University
    †Present addresses: Genetics and Genomics Group, Sanford Research, Sioux Falls, SD 57104, USA (M.S.K.); Molecular and Cellular Biology, University of California Merced, Merced, CA 95343, USA (X.G.); Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA (T.V.); Leibniz-Institute for Molecular Pharmacology, 13125 Berlin, Germany (P.B.); Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama 230-0045, Japan (K.R.N.).)

  • Daniel R. Fuentes

    (Stanford University)

  • Philip Brennecke

    (Stanford University
    †Present addresses: Genetics and Genomics Group, Sanford Research, Sioux Falls, SD 57104, USA (M.S.K.); Molecular and Cellular Biology, University of California Merced, Merced, CA 95343, USA (X.G.); Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA (T.V.); Leibniz-Institute for Molecular Pharmacology, 13125 Berlin, Germany (P.B.); Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama 230-0045, Japan (K.R.N.).)

  • Kazuhiro R. Nitta

    (Karolinska Institutet
    †Present addresses: Genetics and Genomics Group, Sanford Research, Sioux Falls, SD 57104, USA (M.S.K.); Molecular and Cellular Biology, University of California Merced, Merced, CA 95343, USA (X.G.); Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA (T.V.); Leibniz-Institute for Molecular Pharmacology, 13125 Berlin, Germany (P.B.); Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama 230-0045, Japan (K.R.N.).)

  • Arttu Jolma

    (Karolinska Institutet)

  • Lars M. Steinmetz

    (Stanford University
    Genome Biology Unit, European Molecular Biology Laboratory (EMBL))

  • Jussi Taipale

    (Karolinska Institutet
    Genome Scale Biology Program, University of Helsinki)

  • Thomas C. Südhof

    (Stanford University)

  • Marius Wernig

    (Stanford University)

Abstract

The neuron-specific transcription factor Myt1l represses many somatic lineage programs, but not the neuronal lineage program, to both induce and maintain neuronal identity.

Suggested Citation

  • Moritz Mall & Michael S. Kareta & Soham Chanda & Henrik Ahlenius & Nicholas Perotti & Bo Zhou & Sarah D. Grieder & Xuecai Ge & Sienna Drake & Cheen Euong Ang & Brandon M. Walker & Thomas Vierbuchen & , 2017. "Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates," Nature, Nature, vol. 544(7649), pages 245-249, April.
    • Handle: RePEc:nat:nature:v:544:y:2017:i:7649:d:10.1038_nature21722
    DOI: 10.1038/nature21722
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    Cited by:

    1. Gintautas Vainorius & Maria Novatchkova & Georg Michlits & Juliane Christina Baar & Cecilia Raupach & Joonsun Lee & Ramesh Yelagandula & Marius Wernig & Ulrich Elling, 2023. "Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Ravneet Jaura & Ssu-Yu Yeh & Kaitlin N. Montanera & Alyssa Ialongo & Zobia Anwar & Yiming Lu & Kavindu Puwakdandawa & Ho Sung Rhee, 2022. "Extended intergenic DNA contributes to neuron-specific expression of neighboring genes in the mammalian nervous system," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Luke F. Nunnelly & Melissa Campbell & Dylan I. Lee & Patrick Dummer & Guoqiang Gu & Vilas Menon & Edmund Au, 2022. "St18 specifies globus pallidus projection neuron identity in MGE lineage," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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