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SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice

Author

Listed:
  • Tatsuya Yoshizawa

    (Kumamoto University)

  • Yoshifumi Sato

    (Kumamoto University)

  • Shihab U. Sobuz

    (Kumamoto University)

  • Tomoya Mizumoto

    (Kumamoto University)

  • Tomonori Tsuyama

    (Kumamoto University)

  • Md. Fazlul Karim

    (Kumamoto University)

  • Keishi Miyata

    (Kumamoto University)

  • Masayoshi Tasaki

    (Kumamoto University
    Kumamoto University)

  • Masaya Yamazaki

    (Kumamoto University)

  • Yuichi Kariba

    (Kumamoto University
    Kumamoto University)

  • Norie Araki

    (Kumamoto University)

  • Eiichi Araki

    (Kumamoto University
    Kumamoto University)

  • Shingo Kajimura

    (Beth Israel Deaconess Medical Center, Harvard Medical School, and Howard Hughes Medical Institute)

  • Yuichi Oike

    (Kumamoto University
    Kumamoto University)

  • Thomas Braun

    (Max-Planck-Institute for Heart and Lung Research)

  • Eva Bober

    (Max-Planck-Institute for Heart and Lung Research)

  • Johan Auwerx

    (École Polytechnique Fédérale de Lausanne)

  • Kazuya Yamagata

    (Kumamoto University
    Kumamoto University)

Abstract

Brown adipose tissue plays a central role in the regulation of the energy balance by expending energy to produce heat. NAD+-dependent deacylase sirtuins have widely been recognized as positive regulators of brown adipose tissue thermogenesis. However, here we reveal that SIRT7, one of seven mammalian sirtuins, suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions. Whole-body and brown adipose tissue-specific Sirt7 knockout mice have higher body temperature and energy expenditure. SIRT7 deficiency increases the protein level of UCP1, a key regulator of brown adipose tissue thermogenesis. Mechanistically, we found that SIRT7 deacetylates insulin-like growth factor 2 mRNA-binding protein 2, an RNA-binding protein that inhibits the translation of Ucp1 mRNA, thereby enhancing its inhibitory action on Ucp1. Furthermore, SIRT7 attenuates the expression of batokine genes, such as fibroblast growth factor 21. In conclusion, we propose that SIRT7 serves as an energy-saving factor by suppressing brown adipose tissue functions.

Suggested Citation

  • Tatsuya Yoshizawa & Yoshifumi Sato & Shihab U. Sobuz & Tomoya Mizumoto & Tomonori Tsuyama & Md. Fazlul Karim & Keishi Miyata & Masayoshi Tasaki & Masaya Yamazaki & Yuichi Kariba & Norie Araki & Eiichi, 2022. "SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35219-z
    DOI: 10.1038/s41467-022-35219-z
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