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Greater genetic diversity is needed in human pluripotent stem cell models

Author

Listed:
  • Sulagna Ghosh

    (Broad Institute of MIT and Harvard
    Harvard University)

  • Ralda Nehme

    (Broad Institute of MIT and Harvard
    Harvard University)

  • Lindy E. Barrett

    (Broad Institute of MIT and Harvard
    Harvard University)

Abstract

While there are a growing number of human pluripotent stem cell repositories, genetic diversity remains limited in most collections and studies. Here, we discuss the importance of incorporating diverse ancestries in these models to improve equity and accelerate biological discovery.

Suggested Citation

  • Sulagna Ghosh & Ralda Nehme & Lindy E. Barrett, 2022. "Greater genetic diversity is needed in human pluripotent stem cell models," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34940-z
    DOI: 10.1038/s41467-022-34940-z
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    References listed on IDEAS

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    2. Tracey Hurrell & Jerolen Naidoo & Tiro Ntlhafu & Janine Scholefield, 2024. "An African perspective on genetically diverse human induced pluripotent stem cell lines," Nature Communications, Nature, vol. 15(1), pages 1-5, December.
    3. Matthew Tegtmeyer & Jatin Arora & Samira Asgari & Beth A. Cimini & Ajay Nadig & Emily Peirent & Dhara Liyanage & Gregory P. Way & Erin Weisbart & Aparna Nathan & Tiffany Amariuta & Kevin Eggan & Marzi, 2024. "High-dimensional phenotyping to define the genetic basis of cellular morphology," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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