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Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity

Author

Listed:
  • Mengyi Yin

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Wenhua Kuang

    (Chinese Academy of Sciences)

  • Qianran Wang

    (Chinese Academy of Sciences)

  • Xi Wang

    (Chinese Academy of Sciences)

  • Chuanfei Yuan

    (Chinese Academy of Sciences)

  • Zhe Lin

    (Chinese Academy of Sciences)

  • Huanyu Zhang

    (Chinese Academy of Sciences)

  • Fei Deng

    (Chinese Academy of Sciences)

  • Haobo Jiang

    (Oklahoma State University)

  • Peng Gong

    (Chinese Academy of Sciences)

  • Zhen Zou

    (University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Zhihong Hu

    (Chinese Academy of Sciences)

  • Manli Wang

    (Chinese Academy of Sciences)

Abstract

P26, a homolog of the viral-encoded nuclease poxin that neutralizes the cGAS-STING innate immunity, is widely distributed in various invertebrate viruses, lepidopteran insects, and parasitoid wasps. P26/poxin from certain insect viruses also retains protease activity, though its biological role remains unknown. Given that many P26s contain a signal peptide, it is surmised that P26 may possess certain extracellular functions. Here, we report that a secretory baculoviral P26 suppresses melanization, a prominent insect innate immunity against pathogen invasion. P26 targets the cofactor of a prophenoloxidase-activating protease, and its inhibitory function is independent of nuclease activity. The analysis of P26/poxin homologs from different origins suggests that the ability to inhibit the extracellular melanization pathway is limited to P26s with a signal peptide and not shared by the homologs without it. These findings highlight the independent evolution of a single viral suppressor to perform dual roles in modulating immunity during virus-host adaptation.

Suggested Citation

  • Mengyi Yin & Wenhua Kuang & Qianran Wang & Xi Wang & Chuanfei Yuan & Zhe Lin & Huanyu Zhang & Fei Deng & Haobo Jiang & Peng Gong & Zhen Zou & Zhihong Hu & Manli Wang, 2022. "Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34761-0
    DOI: 10.1038/s41467-022-34761-0
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    References listed on IDEAS

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    1. Björn Schwanhäusser & Dorothea Busse & Na Li & Gunnar Dittmar & Johannes Schuchhardt & Jana Wolf & Wei Chen & Matthias Selbach, 2011. "Global quantification of mammalian gene expression control," Nature, Nature, vol. 473(7347), pages 337-342, May.
    2. James B. Eaglesham & Youdong Pan & Thomas S. Kupper & Philip J. Kranzusch, 2019. "Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling," Nature, Nature, vol. 566(7743), pages 259-263, February.
    3. James B. Eaglesham & Youdong Pan & Thomas S. Kupper & Philip J. Kranzusch, 2019. "Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling," Nature, Nature, vol. 569(7758), pages 12-12, May.
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