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Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging

Author

Listed:
  • Benhao Li

    (Fudan University)

  • Mengyao Zhao

    (Fudan University)

  • Lishuai Feng

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Chaoran Dou

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Suwan Ding

    (Fudan University)

  • Gang Zhou

    (Fudan University)

  • Lingfei Lu

    (Fudan University)

  • Hongxin Zhang

    (Fudan University)

  • Feiya Chen

    (Fudan University)

  • Xiaomin Li

    (Fudan University)

  • Guangfeng Li

    (Fudan University)

  • Shichang Zhao

    (Shanghai Jiao Tong University)

  • Chunyu Jiang

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Yan Wang

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Dongyuan Zhao

    (Fudan University)

  • Yingsheng Cheng

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Fan Zhang

    (Fudan University)

Abstract

Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5–60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties.

Suggested Citation

  • Benhao Li & Mengyao Zhao & Lishuai Feng & Chaoran Dou & Suwan Ding & Gang Zhou & Lingfei Lu & Hongxin Zhang & Feiya Chen & Xiaomin Li & Guangfeng Li & Shichang Zhao & Chunyu Jiang & Yan Wang & Dongyua, 2020. "Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16924-z
    DOI: 10.1038/s41467-020-16924-z
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    Cited by:

    1. Chao Mi & Xun Zhang & Chengyu Yang & Jianqun Wu & Xinxin Chen & Chenguang Ma & Sitong Wu & Zhichao Yang & Pengzhen Qiao & Yang Liu & Weijie Wu & Zhiyong Guo & Jiayan Liao & Jiajia Zhou & Ming Guan & C, 2023. "Bone disease imaging through the near-infrared-II window," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Dongya Zhang & Sidan Tian & Yanjie Liu & Meng Zheng & Xiangliang Yang & Yan Zou & Bingyang Shi & Liang Luo, 2022. "Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Rui Tian & Xin Feng & Long Wei & Daoguo Dai & Ying Ma & Haifeng Pan & Shengxiang Ge & Lang Bai & Chaomin Ke & Yanlin Liu & Lixin Lang & Shoujun Zhu & Haitao Sun & Yanbao Yu & Xiaoyuan Chen, 2022. "A genetic engineering strategy for editing near-infrared-II fluorophores," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Jiajun Xu & Ningning Zhu & Yijing Du & Tianyang Han & Xue Zheng & Jia Li & Shoujun Zhu, 2024. "Biomimetic NIR-II fluorescent proteins created from chemogenic protein-seeking dyes for multicolor deep-tissue bioimaging," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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