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Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer

Author

Listed:
  • Sarun Juengpanich

    (Zhejiang University
    Zhejiang University
    Zhejiang University)

  • Shijie Li

    (Zhejiang University
    Zhejiang University)

  • Taorui Yang

    (Zhejiang Sci-Tech University)

  • Tianao Xie

    (Zhejiang University
    Zhejiang University)

  • Jiadong Chen

    (Zhejiang University)

  • Yukai Shan

    (Zhejiang University)

  • Jiyoung Lee

    (Zhejiang University)

  • Ziyi Lu

    (Zhejiang University)

  • Tianen Chen

    (Zhejiang University)

  • Bin Zhang

    (Zhejiang University)

  • Jiasheng Cao

    (Zhejiang University)

  • Jiahao Hu

    (Zhejiang University)

  • Jicheng Yu

    (Zhejiang University
    Zhejiang University
    Zhejiang University
    Zhejiang University Medical Center)

  • Yanfang Wang

    (Zhejiang University)

  • Win Topatana

    (Zhejiang University
    Zhejiang University)

  • Zhen Gu

    (Zhejiang University
    Zhejiang University
    Zhejiang University
    Zhejiang University Medical Center)

  • Xiujun Cai

    (Zhejiang University
    Zhejiang University
    Zhejiang University)

  • Mingyu Chen

    (Zhejiang University
    Zhejiang University
    Zhejiang University)

Abstract

Phototherapy of deep tumors still suffers from many obstacles, such as limited near-infrared (NIR) tissue penetration depth and low accumulation efficiency within the target sites. Herein, stimuli-sensitive tumor-targeted photodynamic nanoparticles (STPNs) with persistent luminescence for the treatment of deep tumors are reported. Purpurin 18 (Pu18), a porphyrin derivative, is utilized as a photosensitizer to produce persistent luminescence in STPNs, while lanthanide-doped upconversion nanoparticles (UCNPs) exhibit bioimaging properties and possess high photostability that can enhance photosensitizer efficacy. STPNs are initially stimulated by NIR irradiation before intravenous administration and accumulate at the tumor site to enter the cells through the HER2 receptor. Due to Pu18 afterglow luminescence properties, STPNs can continuously generate ROS to inhibit NFκB nuclear translocation, leading to tumor cell apoptosis. Moreover, STPNs can be used for diagnostic purposes through MRI and intraoperative NIR navigation. STPNs exceptional antitumor properties combined the advantages of UCNPs and persistent luminescence, representing a promising phototherapeutic strategy for deep tumors.

Suggested Citation

  • Sarun Juengpanich & Shijie Li & Taorui Yang & Tianao Xie & Jiadong Chen & Yukai Shan & Jiyoung Lee & Ziyi Lu & Tianen Chen & Bin Zhang & Jiasheng Cao & Jiahao Hu & Jicheng Yu & Yanfang Wang & Win Topa, 2023. "Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41389-1
    DOI: 10.1038/s41467-023-41389-1
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    References listed on IDEAS

    as
    1. Dongya Zhang & Sidan Tian & Yanjie Liu & Meng Zheng & Xiangliang Yang & Yan Zou & Bingyang Shi & Liang Luo, 2022. "Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
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