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Near-atomic, non-icosahedrally averaged structure of giant virus Paramecium bursaria chlorella virus 1

Author

Listed:
  • Qianqian Shao

    (Sun Yat-sen University)

  • Irina V. Agarkova

    (University of Nebraska-Lincoln)

  • Eric A. Noel

    (University of Nebraska-Lincoln)

  • David D. Dunigan

    (University of Nebraska-Lincoln)

  • Yunshu Liu

    (Sun Yat-sen University)

  • Aohan Wang

    (Sun Yat-sen University)

  • Mingcheng Guo

    (Sun Yat-sen University)

  • Linlin Xie

    (Sun Yat-sen University)

  • Xinyue Zhao

    (Sun Yat-sen University)

  • Michael G. Rossmann

    (Purdue University)

  • James L. Etten

    (University of Nebraska-Lincoln)

  • Thomas Klose

    (Purdue University)

  • Qianglin Fang

    (Sun Yat-sen University
    Purdue University)

Abstract

Giant viruses are a large group of viruses that infect many eukaryotes. Although components that do not obey the overall icosahedral symmetry of their capsids have been observed and found to play critical roles in the viral life cycles, identities and high-resolution structures of these components remain unknown. Here, by determining a near-atomic-resolution, five-fold averaged structure of Paramecium bursaria chlorella virus 1, we unexpectedly found the viral capsid possesses up to five major capsid protein variants and a penton protein variant. These variants create varied capsid microenvironments for the associations of fibers, a vesicle, and previously unresolved minor capsid proteins. Our structure reveals the identities and atomic models of the capsid components that do not obey the overall icosahedral symmetry and leads to a model for how these components are assembled and initiate capsid assembly, and this model might be applicable to many other giant viruses.

Suggested Citation

  • Qianqian Shao & Irina V. Agarkova & Eric A. Noel & David D. Dunigan & Yunshu Liu & Aohan Wang & Mingcheng Guo & Linlin Xie & Xinyue Zhao & Michael G. Rossmann & James L. Etten & Thomas Klose & Qiangli, 2022. "Near-atomic, non-icosahedrally averaged structure of giant virus Paramecium bursaria chlorella virus 1," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34218-4
    DOI: 10.1038/s41467-022-34218-4
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    References listed on IDEAS

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    1. Kathryn Tunyasuvunakool & Jonas Adler & Zachary Wu & Tim Green & Michal Zielinski & Augustin Žídek & Alex Bridgland & Andrew Cowie & Clemens Meyer & Agata Laydon & Sameer Velankar & Gerard J. Kleywegt, 2021. "Highly accurate protein structure prediction for the human proteome," Nature, Nature, vol. 596(7873), pages 590-596, August.
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    3. Qianglin Fang & Dongjie Zhu & Irina Agarkova & Jagat Adhikari & Thomas Klose & Yue Liu & Zhenguo Chen & Yingyuan Sun & Michael L. Gross & James L. Van Etten & Xinzheng Zhang & Michael G. Rossmann, 2019. "Near-atomic structure of a giant virus," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
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