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Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration

Author

Listed:
  • Allah Nawaz

    (University of Toyama
    University of Toyama
    Joslin Diabetes Center)

  • Muhammad Bilal

    (University of Toyama)

  • Shiho Fujisaka

    (University of Toyama)

  • Tomonobu Kado

    (University of Toyama)

  • Muhammad Rahil Aslam

    (University of Toyama)

  • Saeed Ahmed

    (Rawalpindi Medical University)

  • Keisuke Okabe

    (University of Toyama
    University of Toyama)

  • Yoshiko Igarashi

    (University of Toyama)

  • Yoshiyuki Watanabe

    (University of Toyama)

  • Takahide Kuwano

    (University of Toyama)

  • Koichi Tsuneyama

    (Tokushima University Graduate School)

  • Ayumi Nishimura

    (University of Toyama)

  • Yasuhiro Nishida

    (University of Toyama)

  • Seiji Yamamoto

    (University of Toyama)

  • Masakiyo Sasahara

    (University of Toyama)

  • Johji Imura

    (University of Toyama)

  • Hisashi Mori

    (University of Toyama)

  • Martin M. Matzuk

    (Baylor College of Medicine)

  • Fujimi Kudo

    (Chiba University Graduate School of Medicine)

  • Ichiro Manabe

    (Chiba University Graduate School of Medicine)

  • Akiyoshi Uezumi

    (Tokushima University)

  • Takashi Nakagawa

    (University of Toyama)

  • Yumiko Oishi

    (Nippon Medical School)

  • Kazuyuki Tobe

    (University of Toyama)

Abstract

Muscle regeneration requires the coordination of muscle stem cells, mesenchymal fibro-adipogenic progenitors (FAPs), and macrophages. How macrophages regulate the paracrine secretion of FAPs during the recovery process remains elusive. Herein, we systemically investigated the communication between CD206+ M2-like macrophages and FAPs during the recovery process using a transgenic mouse model. Depletion of CD206+ M2-like macrophages or deletion of CD206+ M2-like macrophages-specific TGF-β1 gene induces myogenesis and muscle regeneration. We show that depletion of CD206+ M2-like macrophages activates FAPs and activated FAPs secrete follistatin, a promyogenic factor, thereby boosting the recovery process. Conversely, deletion of the FAP-specific follistatin gene results in impaired muscle stem cell function, enhanced fibrosis, and delayed muscle regeneration. Mechanistically, CD206+ M2-like macrophages inhibit the secretion of FAP-derived follistatin via TGF-β signaling. Here we show that CD206+ M2-like macrophages constitute a microenvironment for FAPs and may regulate the myogenic potential of muscle stem/satellite cells.

Suggested Citation

  • Allah Nawaz & Muhammad Bilal & Shiho Fujisaka & Tomonobu Kado & Muhammad Rahil Aslam & Saeed Ahmed & Keisuke Okabe & Yoshiko Igarashi & Yoshiyuki Watanabe & Takahide Kuwano & Koichi Tsuneyama & Ayumi , 2022. "Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34191-y
    DOI: 10.1038/s41467-022-34191-y
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    References listed on IDEAS

    as
    1. Min Shang & Federica Cappellesso & Ricardo Amorim & Jens Serneels & Federico Virga & Guy Eelen & Stefania Carobbio & Melvin Y. Rincon & Pierre Maechler & Katrien Bock & Ping-Chih Ho & Marco Sandri & B, 2020. "Macrophage-derived glutamine boosts satellite cells and muscle regeneration," Nature, Nature, vol. 587(7835), pages 626-631, November.
    2. M. S. Magalhaes & P. Smith & J. R. Portman & L. H. Jackson-Jones & C. C. Bain & P. Ramachandran & Z. Michailidou & R. H. Stimson & M. R. Dweck & L. Denby & N. C. Henderson & S. J. Jenkins & C. Bénézec, 2021. "Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    3. Allah Nawaz & Aminuddin Aminuddin & Tomonobu Kado & Akiko Takikawa & Seiji Yamamoto & Koichi Tsuneyama & Yoshiko Igarashi & Masashi Ikutani & Yasuhiro Nishida & Yoshinori Nagai & Kiyoshi Takatsu & Joh, 2017. "CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors," Nature Communications, Nature, vol. 8(1), pages 1-16, December.
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    5. Yingyao Zhou & Bin Zhou & Lars Pache & Max Chang & Alireza Hadj Khodabakhshi & Olga Tanaseichuk & Christopher Benner & Sumit K. Chanda, 2019. "Metascape provides a biologist-oriented resource for the analysis of systems-level datasets," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    Full references (including those not matched with items on IDEAS)

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