IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_s41467-017-00231-1.html
   My bibliography  Save this article

CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors

Author

Listed:
  • Allah Nawaz

    (University of Toyama)

  • Aminuddin Aminuddin

    (University of Toyama
    Faculty of Medicine, University of Hasanuddin)

  • Tomonobu Kado

    (University of Toyama)

  • Akiko Takikawa

    (University of Toyama)

  • Seiji Yamamoto

    (University of Toyama)

  • Koichi Tsuneyama

    (University of Toyama
    Institute of Biomedical Sciences, Tokushima University Graduate School)

  • Yoshiko Igarashi

    (University of Toyama)

  • Masashi Ikutani

    (National Center for Global Health and Medicine)

  • Yasuhiro Nishida

    (University of Toyama)

  • Yoshinori Nagai

    (University of Toyama
    JST, PRESTO)

  • Kiyoshi Takatsu

    (University of Toyama
    Toyama Prefectural Institute for Pharmaceutical Research)

  • Johji Imura

    (University of Toyama)

  • Masakiyo Sasahara

    (University of Toyama)

  • Yukiko Okazaki

    (The University of Tokyo)

  • Kohjiro Ueki

    (The University of Tokyo
    National Center for Global Health and Medicine)

  • Tadashi Okamura

    (National Center for Global Health and Medicine
    National Center for Global Health and Medicine)

  • Kumpei Tokuyama

    (University of Tsukuba)

  • Akira Ando

    (University of Tsukuba)

  • Michihiro Matsumoto

    (National Center for Global Health and Medicine)

  • Hisashi Mori

    (University of Toyama)

  • Takashi Nakagawa

    (University of Toyama)

  • Norihiko Kobayashi

    (National Center for Global Health and Medicine)

  • Kumiko Saeki

    (National Center for Global Health and Medicine)

  • Isao Usui

    (University of Toyama)

  • Shiho Fujisaka

    (University of Toyama)

  • Kazuyuki Tobe

    (University of Toyama)

Abstract

Adipose tissue resident macrophages have important roles in the maintenance of tissue homeostasis and regulate insulin sensitivity for example by secreting pro-inflammatory or anti-inflammatory cytokines. Here, we show that M2-like macrophages in adipose tissue regulate systemic glucose homeostasis by inhibiting adipocyte progenitor proliferation via the CD206/TGFβ signaling pathway. We show that adipose tissue CD206+ cells are primarily M2-like macrophages, and ablation of CD206+ M2-like macrophages improves systemic insulin sensitivity, which was associated with an increased number of smaller adipocytes. Mice genetically engineered to have reduced numbers of CD206+ M2-like macrophages show a down-regulation of TGFβ signaling in adipose tissue, together with up-regulated proliferation and differentiation of adipocyte progenitors. Our findings indicate that CD206+ M2-like macrophages in adipose tissues create a microenvironment that inhibits growth and differentiation of adipocyte progenitors and, thereby, control adiposity and systemic insulin sensitivity.

Suggested Citation

  • Allah Nawaz & Aminuddin Aminuddin & Tomonobu Kado & Akiko Takikawa & Seiji Yamamoto & Koichi Tsuneyama & Yoshiko Igarashi & Masashi Ikutani & Yasuhiro Nishida & Yoshinori Nagai & Kiyoshi Takatsu & Joh, 2017. "CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors," Nature Communications, Nature, vol. 8(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00231-1
    DOI: 10.1038/s41467-017-00231-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-00231-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-00231-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Allah Nawaz & Muhammad Bilal & Shiho Fujisaka & Tomonobu Kado & Muhammad Rahil Aslam & Saeed Ahmed & Keisuke Okabe & Yoshiko Igarashi & Yoshiyuki Watanabe & Takahide Kuwano & Koichi Tsuneyama & Ayumi , 2022. "Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Dongliang Lu & Anyuan He & Min Tan & Marguerite Mrad & Amal El Daibani & Donghua Hu & Xuejing Liu & Brian Kleiboeker & Tao Che & Fong-Fu Hsu & Monika Bambouskova & Clay F. Semenkovich & Irfan J. Lodhi, 2024. "Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Jingjing Qi & Hongxiang Sun & Yao Zhang & Zhengting Wang & Zhenzhen Xun & Ziyi Li & Xinyu Ding & Rujuan Bao & Liwen Hong & Wenqing Jia & Fei Fang & Hongzhi Liu & Lei Chen & Jie Zhong & Duowu Zou & Lia, 2022. "Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00231-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.