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Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex

Author

Listed:
  • Hidenori Tabata

    (Aichi Developmental Disability Center
    Keio University School of Medicine)

  • Megumi Sasaki

    (Keio University School of Medicine)

  • Masakazu Agetsuma

    (National Institute for Physiological Sciences)

  • Hitomi Sano

    (Keio University School of Medicine)

  • Yuki Hirota

    (Keio University School of Medicine)

  • Michio Miyajima

    (Keio University School of Medicine)

  • Kanehiro Hayashi

    (Keio University School of Medicine)

  • Takao Honda

    (Keio University School of Medicine)

  • Masashi Nishikawa

    (Aichi Developmental Disability Center)

  • Yutaka Inaguma

    (Aichi Developmental Disability Center)

  • Hidenori Ito

    (Aichi Developmental Disability Center)

  • Hirohide Takebayashi

    (Niigata University)

  • Masatsugu Ema

    (Shiga University of Medical Science)

  • Kazuhiro Ikenaka

    (National Institute for Physiological Sciences)

  • Junichi Nabekura

    (National Institute for Physiological Sciences)

  • Koh-ichi Nagata

    (Aichi Developmental Disability Center)

  • Kazunori Nakajima

    (Keio University School of Medicine)

Abstract

Astrocytes are one of the most abundant cell types in the mammalian brain. They play essential roles in synapse formation, maturation, and elimination. However, how astrocytes migrate into the gray matter to accomplish these processes is poorly understood. Here, we show that, by combinational analyses of in vitro and in vivo time-lapse observations and lineage traces, astrocyte progenitors move rapidly and irregularly within the developing cortex, which we call erratic migration. Astrocyte progenitors also adopt blood vessel-guided migration. These highly motile progenitors are generated in the restricted prenatal stages and differentiate into protoplasmic astrocytes in the gray matter, whereas postnatally generated progenitors do not move extensively and differentiate into fibrous astrocytes in the white matter. We found Cxcr4/7, and integrin β1 regulate the blood vessel-guided migration, and their functional blocking disrupts their positioning. This study provides insight into astrocyte development and may contribute to understanding the pathogenesis caused by their defects.

Suggested Citation

  • Hidenori Tabata & Megumi Sasaki & Masakazu Agetsuma & Hitomi Sano & Yuki Hirota & Michio Miyajima & Kanehiro Hayashi & Takao Honda & Masashi Nishikawa & Yutaka Inaguma & Hidenori Ito & Hirohide Takeba, 2022. "Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34184-x
    DOI: 10.1038/s41467-022-34184-x
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