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Cortical astrocytes develop in a plastic manner at both clonal and cellular levels

Author

Listed:
  • Solène Clavreul

    (Sorbonne Université, INSERM, CNRS, Institut de la Vision)

  • Lamiae Abdeladim

    (Ecole polytechnique, CNRS, INSERM, IP Paris)

  • Edwin Hernández-Garzón

    (CNRS UMR 9199, Université Paris-Sud, Université Paris-Saclay)

  • Dragos Niculescu

    (Sorbonne Université, INSERM, CNRS, Institut de la Vision)

  • Jason Durand

    (Sorbonne Université, INSERM, CNRS, Institut de la Vision)

  • Sio-Hoï Ieng

    (Sorbonne Université, INSERM, CNRS, Institut de la Vision)

  • Raphaëlle Barry

    (Sorbonne Université, INSERM, CNRS, Institut de la Vision)

  • Gilles Bonvento

    (CNRS UMR 9199, Université Paris-Sud, Université Paris-Saclay)

  • Emmanuel Beaurepaire

    (Ecole polytechnique, CNRS, INSERM, IP Paris)

  • Jean Livet

    (Sorbonne Université, INSERM, CNRS, Institut de la Vision)

  • Karine Loulier

    (Sorbonne Université, INSERM, CNRS, Institut de la Vision
    Institut des Neurosciences de Montpellier, INSERM U1051)

Abstract

Astrocytes play essential roles in the neural tissue where they form a continuous network, while displaying important local heterogeneity. Here, we performed multiclonal lineage tracing using combinatorial genetic markers together with a new large volume color imaging approach to study astrocyte development in the mouse cortex. We show that cortical astrocyte clones intermix with their neighbors and display extensive variability in terms of spatial organization, number and subtypes of cells generated. Clones develop through 3D spatial dispersion, while at the individual level astrocytes acquire progressively their complex morphology. Furthermore, we find that the astroglial network is supplied both before and after birth by ventricular progenitors that scatter in the neocortex and can give rise to protoplasmic as well as pial astrocyte subtypes. Altogether, these data suggest a model in which astrocyte precursors colonize the neocortex perinatally in a non-ordered manner, with local environment likely determining astrocyte clonal expansion and final morphotype.

Suggested Citation

  • Solène Clavreul & Lamiae Abdeladim & Edwin Hernández-Garzón & Dragos Niculescu & Jason Durand & Sio-Hoï Ieng & Raphaëlle Barry & Gilles Bonvento & Emmanuel Beaurepaire & Jean Livet & Karine Loulier, 2019. "Cortical astrocytes develop in a plastic manner at both clonal and cellular levels," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12791-5
    DOI: 10.1038/s41467-019-12791-5
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    Cited by:

    1. Hidenori Tabata & Megumi Sasaki & Masakazu Agetsuma & Hitomi Sano & Yuki Hirota & Michio Miyajima & Kanehiro Hayashi & Takao Honda & Masashi Nishikawa & Yutaka Inaguma & Hidenori Ito & Hirohide Takeba, 2022. "Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Moises Freitas-Andrade & Cesar H. Comin & Peter Dyken & Julie Ouellette & Joanna Raman-Nair & Nicole Blakeley & Qing Yan Liu & Sonia Leclerc & Youlian Pan & Ziying Liu & Micaël Carrier & Karan Thakur , 2023. "Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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